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    Ypel3 yippee-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293491, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ypel3provided by RGD
    Official Full Name
    yippee-like 3provided by RGD
    Primary source
    RGD:1564579
    See related
    EnsemblRapid:ENSRNOG00000019721 AllianceGenome:RGD:1564579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564579
    Summary
    Predicted to be involved in positive regulation of cellular senescence. Predicted to be located in nucleus. Orthologous to human YPEL3 (yippee like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 254.3), Thymus (RPKM 243.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ypel3 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190814920..190818248)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181384385..181387706)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198210525..198213821)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mitogen activated protein kinase 3 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene T-box transcription factor 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene uncharacterized LOC103691235 Neighboring gene aldolase, fructose-bisphosphate A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. YPEL3, a p53-regulated gene that induces cellular senescence. Kelley KD, et al. Cancer Res, 2010 May 1. PMID 20388804, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein yippee-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135698.1 → NP_001129170.1  protein yippee-like 3

      See identical proteins and their annotated locations for NP_001129170.1

      Status: VALIDATED

      Source sequence(s)
      CB582520, DV728986
      UniProtKB/TrEMBL
      A0A8I6ADG9, A6I9D3
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190814920..190818248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107344.2 → XP_038963272.1  protein yippee-like 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRX0, A6I9D0, A6I9D1
      Related
      ENSRNOP00000081549.1, ENSRNOT00000119813.2
      Conserved Domains (1) summary
      cl13152
      Location:50 → 139
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    2. XM_006230235.4 → XP_006230297.1  protein yippee-like 3 isoform X2

      See identical proteins and their annotated locations for XP_006230297.1

      UniProtKB/TrEMBL
      A0A8I6ADG9, A6I9D3
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    3. XM_039107339.2 → XP_038963267.1  protein yippee-like 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADG9, A6I9D3
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    4. XM_039107336.2 → XP_038963264.1  protein yippee-like 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADG9, A6I9D3
      Related
      ENSRNOP00000077317.2, ENSRNOT00000095600.2
      Conserved Domains (1) summary
      cl13152
      Location:21 → 110
      RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

    5. XM_063286133.1 → XP_063142203.1  protein yippee-like 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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