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    Denr density regulated reinitiation and release factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687565, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Denrprovided by RGD
    Official Full Name
    density regulated reinitiation and release factorprovided by RGD
    Primary source
    RGD:1584200
    See related
    EnsemblRapid:ENSRNOG00000001106 AllianceGenome:RGD:1584200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable translation initiation factor activity. Predicted to be involved in IRES-dependent viral translational initiation; cytoplasmic translational initiation; and ribosome disassembly. Predicted to be active in cytoplasm. Orthologous to human DENR (density regulated re-initiation and release factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 118.9), Brain (RPKM 115.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Denr in Genome Data Viewer
    Location:
    12q15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (38323433..38346207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32662512..32685283, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (38095717..38117758, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene huntingtin interacting protein 1 related Neighboring gene coiled-coil domain containing 62 Neighboring gene hydroxycarboxylic acid receptor 1 Neighboring gene hydroxycarboxylic acid receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling. Skabkin MA, et al. Genes Dev, 2010 Aug 15. PMID 20713520, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRES-dependent viral translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation reinitiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    density-regulated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115046.2 → NP_001108518.1  density-regulated protein

      See identical proteins and their annotated locations for NP_001108518.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158753
      UniProtKB/TrEMBL
      B0BNB2, D3ZU54
      Related
      ENSRNOP00000001467.9, ENSRNOT00000001467.9
      Conserved Domains (1) summary
      TIGR01159
      Location:24 → 189
      DRP1; density-regulated protein DRP1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      38323433..38346207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089758.2 → XP_038945686.1  density-regulated protein isoform X1

      UniProtKB/TrEMBL
      B0BNB2, D3ZU54
      Conserved Domains (1) summary
      TIGR01159
      Location:24 → 189
      DRP1; density-regulated protein DRP1

    2. XM_039089759.2 → XP_038945687.1  density-regulated protein isoform X2

      Conserved Domains (1) summary
      cl00229
      Location:24 → 134
      eIF1_SUI1_like; Eukaryotic initiation factor 1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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