Fntb farnesyltransferase, CAAX box, subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fntbprovided by RGD
Official Full Name: farnesyltransferase, CAAX box, subunit betaprovided by RGD
Primary source: RGD:620119
See related: EnsemblRapid:ENSRNOG00000071324 AllianceGenome:RGD:620119
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Contributes to peptide binding activity and protein farnesyltransferase activity. Involved in positive regulation of cell cycle; positive regulation of cell population proliferation; and response to organic cyclic compound. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to several human genes including FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 61.5), Brain (RPKM 50.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (101269657..101352716)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (95536540..95619587)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (99883959..99966988)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that substrate specificity of protein farnesyltransferase (subunits Fnta plus Fntb) is extensive; these results expand the scope of the potential prenylated proteome in this species. (Fnta = farnesyltransferase CAAX box alpha protein; Fntb = farnesyltransferase CAAX box beta protein)
Title: Efficient farnesylation of an extended C-terminal C(x)(3)X sequence motif expands the scope of the prenylated proteome.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables farnesyltranstransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to protein farnesyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein farnesyltransferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in prenylation	IEA Inferred from Electronic Annotation more info
involved_in protein farnesylation	ISO Inferred from Sequence Orthology more info
involved_in protein farnesylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of microtubule associated complex	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of protein farnesyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of protein farnesyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein farnesyltransferase subunit beta

Names: CAAX farnesyltransferase subunit beta; FTase-beta; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; ras proteins prenyltransferase subunit beta

NP_742031.1

EC 2.5.1.58

XP_038968805.1

EC 2.5.1.58

XP_063118516.1

EC 2.5.1.58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172034.2 → NP_742031.1 protein farnesyltransferase subunit beta

See identical proteins and their annotated locations for NP_742031.1

Status: PROVISIONAL

Source sequence(s)

BC087675

UniProtKB/Swiss-Prot

Q02293

UniProtKB/TrEMBL

A6HCB6

Related

ENSRNOP00000109911.1, ENSRNOT00000121059.2

Conserved Domains (1) summary

cd02893
Location:75 → 373

FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

101269657..101352716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112877.2 → XP_038968805.1 protein farnesyltransferase subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I5ZMQ9

Related

ENSRNOP00000079445.1, ENSRNOT00000099844.3

Conserved Domains (1) summary

cd02893
Location:75 → 344

FTase; Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the ...
XM_063262446.1 → XP_063118516.1 protein farnesyltransferase subunit beta isoform X2