Apoa1 apolipoprotein A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25081, updated on 27-Dec-2024

Summary

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Official Symbol: Apoa1provided by RGD
Official Full Name: apolipoprotein A1provided by RGD
Primary source: RGD:2130
See related: EnsemblRapid:ENSRNOG00000045679 AllianceGenome:RGD:2130
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: apoA-I
Summary: Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including negative regulation of lipase activity; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface and extracellular space. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including artery disease (multiple); major depressive disorder; ocular hypertension; sciatic neuropathy; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 17215.8) See more
Orthologs: human mouse all
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Genomic context

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See Apoa1 in Genome Data Viewer

Location:: 8q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (55423945..55425729)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (46527251..46529035)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (50525091..50526875)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-terminal truncation of apoA-I by chymase released from cardiac mast cells during ischemia impairs the ability of apoA-I to heal damaged endothelium in the ischemic myocardium
Title: Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192) and compromises its cardioprotective activity.
both the route of administration and the formulation of apoA-I peptide significantly affect its pharmacokinetics and pharmacodynamics.
Title: Influence of route of administration and lipidation of apolipoprotein A-I peptide on pharmacokinetics and cholesterol mobilization.
ABCA1 is diminished and ABCG1 is increased by N-acetylcysteine, which counteracts the reduction in apo A-I-mediated cholesterol efflux
Title: N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1.
Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes.
Title: Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes.
ApoA-I may be a protective blood-borne factor involved in the remote ischemic preconditioning mechanism.
Title: Apolipoprotein a-I is a potential mediator of remote ischemic preconditioning.
It maintains cholesterol homeostasis.
Title: Curcumin induces ABCA1 expression and apolipoprotein A-I-mediated cholesterol transmembrane in the chronic cerebral hypoperfusion aging rats.
on neonatal rat ventricular cardiomyocytes, the aldosterone-dependent chronotropic effects of antiapoA-1 IgG involve the nongenomic activation of L-type calcium channels
Title: Antiapolipoprotein A-1 IgG chronotropic effects require nongenomic action of aldosterone on L-type calcium channels.
ApoA-I reduced I/R-induced inflammatory responses, decreased renal microscopic damage and improved renal function. ApoA-I protects kidney from I/R injury by inhibiting inflammatory cytokines release and neutrophil infiltration and activation.
Title: Apolipoprotein A-I attenuates renal ischemia/reperfusion injury in rats.
Data show that a complex of apolipoprotein A-I and pregnenolone modulate the rate of protein biosynthesis in liver cells.
Title: Effect of complexes of apolipoprotein A-I with tetrahydrocortisol and pregnenolone on protein biosynthesis in rat hepatocytes culture.
translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s).
Title: Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Arb27 (e-PCR), detects polymorphism
- UniSTS:228202

Apoa1 (e-PCR), detects polymorphism
- UniSTS:502676

RH94461 (e-PCR)
- UniSTS:119709

Apoa1 (e-PCR), detects polymorphism
- UniSTS:532415

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein A-I receptor binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I receptor binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein receptor binding	ISO Inferred from Sequence Orthology more info
enables chemorepellent activity	IEA Inferred from Electronic Annotation more info
enables chemorepellent activity	ISO Inferred from Sequence Orthology more info
enables cholesterol binding	IEA Inferred from Electronic Annotation more info
enables cholesterol binding	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
contributes_to cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables high-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid transporter activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acylglycerol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within axon regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipoprotein particle stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipoprotein particle stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol import	IEA Inferred from Electronic Annotation more info
involved_in cholesterol import	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucocorticoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion molecule production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-methionine modification	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transferase activity	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein oxidation	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Cdc42 protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of Cdc42 protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
NOT involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vitamin transport	IEA Inferred from Electronic Annotation more info
involved_in vitamin transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
part_of discoidal high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of low-density lipoprotein particle	IDA Inferred from Direct Assay more info	PubMed
part_of spherical high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein A-I

Names: apo-AI; apolipoprotein A-1; preproapolipoprotein A-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.