Ggcx gamma-glutamyl carboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ggcxprovided by RGD
Official Full Name: gamma-glutamyl carboxylaseprovided by RGD
Primary source: RGD:68383
See related: EnsemblRapid:ENSRNOG00000012975 AllianceGenome:RGD:68383
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables gamma-glutamyl carboxylase activity and vitamin binding activity. Involved in several processes, including lung growth; peptidyl-glutamic acid carboxylation; and response to dexamethasone. Predicted to be located in endomembrane system and membrane. Predicted to be active in endoplasmic reticulum membrane. Biomarker of urolithiasis. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 1. Orthologous to human GGCX (gamma-glutamyl carboxylase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 261.8), Lung (RPKM 213.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106027918..106043653)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104469737..104485631)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100277345..100293097)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In a rat model of chronic kidney disease, there was a decrease in the thoracic aorta expression of Vkor and Ggcx enzymes, and a decrease in the kidney level of vitamin K1 to MK-4 bioconversion enzyme Ubiad1.
Title: Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease.
gamma-Carboxylase inhibition prevents osteocalcin carboxylation and protects against diabetic cardiomyopathy, possibly through direct action on upregulated G protein-coupled receptor family C group 6 member A and indirectly via adiponectin.
Title: Effect of gamma-carboxylase inhibition on serum osteocalcin may be partially protective against developing diabetic cardiomyopathy in type 2 diabetic rats.
reduced gamma-Carboxylated MGP (cMGP), through an impaired expression of gamma-carboxylase, is involved in the early development of Medial artery calcification (MAC)in diabetes.
Title: Decreased expression of γ-carboxylase in diabetes-associated arterial stiffness: impact on matrix Gla protein.
Both carboxylase activity and formation of gamma-carboxyglutamate (Gla)-containing proteins were stimulated by dexamethasone (Dex) in fetal type II lung cells
Title: Glucocorticoid effects on vitamin K-dependent carboxylase activity and matrix Gla protein expression in rat lung.

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General gene information

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Markers

RH140466 (e-PCR)
- UniSTS:222540

RH133207 (e-PCR)
- UniSTS:216490

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables gamma-glutamyl carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-glutamyl carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-glutamyl carboxylase activity	IEA Inferred from Electronic Annotation more info
enables gamma-glutamyl carboxylase activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IC Inferred by Curator more info	PubMed
enables vitamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables vitamin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lung growth	IEP Inferred from Expression Pattern more info	PubMed
involved_in peptidyl-glutamic acid carboxylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-glutamic acid carboxylation	ISO Inferred from Sequence Orthology more info
involved_in response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxygen levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to parathyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin K	IEP Inferred from Expression Pattern more info	PubMed
involved_in vitamin K metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin K metabolic process	IEA Inferred from Electronic Annotation more info
involved_in vitamin K metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vitamin K-dependent gamma-carboxylase

Names: peptidyl-glutamate 4-carboxylase; vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-glutamyl carboxylase

NP_113944.1

EC 4.1.1.90

XP_017448398.1

EC 4.1.1.90

XP_063142819.1

EC 4.1.1.90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031756.1 → NP_113944.1 vitamin K-dependent gamma-carboxylase

See identical proteins and their annotated locations for NP_113944.1

Status: PROVISIONAL

Source sequence(s)

AF065387

UniProtKB/Swiss-Prot

O88496

UniProtKB/TrEMBL

A0A8I6AAB6, B5DEF3, F7FCW3

Related

ENSRNOP00000088854.1, ENSRNOT00000107225.2

Conserved Domains (2) summary

smart00752
Location:56 → 315

HTTM; Horizontally Transferred TransMembrane Domain

pfam05090
Location:66 → 502

VKG_Carbox; Vitamin K-dependent gamma-carboxylase