Sprtn SprT-like N-terminal domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sprtnprovided by MGI
Official Full Name: SprT-like N-terminal domainprovided by MGI
Primary source: MGI:MGI:2685351
See related: Ensembl:ENSMUSG00000031986 AllianceGenome:MGI:2685351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm505
Summary: Predicted to enable several functions, including DNA binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and metalloendopeptidase activity. Involved in protein-DNA covalent cross-linking repair. Predicted to be located in chromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 49.2), thymus adult (RPKM 7.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 72.83 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (125624612..125632903)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (124897771..124906161)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It has been shown that the livers of Sprtn deficient mice accumulate DNA-protein crosslinks containing Topoisomerase 1 covalently linked to DNA.
Title: Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.
The data demonstrate that Spartan plays a key role in maintaining structural and numerical chromosome integrity and suggest a link between Spartan insufficiency and progeria.
Title: Spartan deficiency causes genomic instability and progeroid phenotypes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info
involved_in interstrand cross-link repair	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-DNA covalent cross-linking repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-DNA covalent cross-linking repair	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA-dependent metalloprotease SPRTN

Names: protein with SprT-like domain at the N terminus; spartan; sprT-like domain-containing protein Spartan

NP_001104611.1

EC 3.4.24.-

XP_006531083.1

EC 3.4.24.-

XP_036009942.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111141.2 → NP_001104611.1 DNA-dependent metalloprotease SPRTN isoform 1

See identical proteins and their annotated locations for NP_001104611.1

Status: VALIDATED

Source sequence(s)

AC139158

Consensus CDS

CCDS52705.1

UniProtKB/Swiss-Prot

B2RY42, G3X912

Related

ENSMUSP00000034467.6, ENSMUST00000034467.7

Conserved Domains (2) summary

smart00734
Location:462 → 485

ZnF_Rad18; Rad18-like CCHC zinc finger

pfam10263
Location:46 → 214

SprT-like; SprT-like family
NM_001428364.1 → NP_001415293.1 DNA-dependent metalloprotease SPRTN isoform 2

Status: VALIDATED

Source sequence(s)

AC139158
NM_001428365.1 → NP_001415294.1 DNA-dependent metalloprotease SPRTN isoform 3

Status: VALIDATED

Source sequence(s)

AC139158
NM_001428366.1 → NP_001415295.1 DNA-dependent metalloprotease SPRTN isoform 4

Status: VALIDATED

Source sequence(s)

AC139158
NM_001428367.1 → NP_001415296.1 DNA-dependent metalloprotease SPRTN isoform 5

Status: VALIDATED

Source sequence(s)

AC139158

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

125624612..125632903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154049.1 → XP_036009942.1 DNA-dependent metalloprotease SPRTN isoform X1

Conserved Domains (3) summary

smart00734
Location:419 → 442

ZnF_Rad18; Rad18-like CCHC zinc finger

COG5432
Location:375 → 442

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

cl19237
Location:44 → 170

DUF45; Protein of unknown function DUF45
XM_006531020.5 → XP_006531083.1 DNA-dependent metalloprotease SPRTN isoform X2

Conserved Domains (3) summary

smart00734
Location:375 → 398

ZnF_Rad18; Rad18-like CCHC zinc finger

smart00731
Location:1 → 126

SprT; SprT homologues

COG5432
Location:331 → 398

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]