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    Stk33 serine/threonine kinase 33 [ Mus musculus (house mouse) ]

    Gene ID: 117229, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stk33provided by MGI
    Official Full Name
    serine/threonine kinase 33provided by MGI
    Primary source
    MGI:MGI:2152419
    See related
    Ensembl:ENSMUSG00000031027 AllianceGenome:MGI:2152419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921505G21Rik
    Summary
    Enables protein serine/threonine kinase activity. Involved in manchette assembly and protein autophosphorylation. Located in manchette. Is expressed in several structures, including central nervous system; heart; lung; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. Orthologous to human STK33 (serine/threonine kinase 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 30.5) and CNS E11.5 (RPKM 1.6) See more
    Orthologs
    human all
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    Genomic context

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    See Stk33 in Genome Data Viewer
    Location:
    7 E3; 7 57.21 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108878270..109038375, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109279213..109439168, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:116409223-116409433 Neighboring gene predicted gene, 32563 Neighboring gene predicted gene, 51463 Neighboring gene STARR-seq mESC enhancer starr_19795 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 pseudogene Neighboring gene RIKEN cDNA 1700095J03 gene Neighboring gene tripartite motif-containing 66 Neighboring gene STARR-seq mESC enhancer starr_19797 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Ku AF, et al. Science, 2024 May 24. PMID 38781365
    2. STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells. Zhou M, et al. J Cell Mol Med, 2018 Nov. PMID 30256516, Free PMC Article
    3. Stk33 is required for spermatid differentiation and male fertility in mice. Martins LR, et al. Dev Biol, 2018 Jan 1. PMID 29155043
    4. STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis. Yu W, et al. Mol Cell Proteomics, 2023 Jun. PMID 37146716, Free PMC Article
    5. A novel serine/threonine kinase gene, STK33, on human chromosome 11p15.3. Mujica AO, et al. Gene, 2001 Dec 12. PMID 11738831

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.
      Title: STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.
    2. he findings from this work indicate that STK33 decreases the sensitivity to the apoptosis dependent on mitochondrial apoptotic pathway by regulating ROS generation after gentamicin treatment, which provides a new potential target for protection from the aminoglycoside-induced ototoxicity.
      Title: STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells.
    3. Stk33 protein resides in the cytoplasm and partially co-localizes with the caudal end of the manchette, a transient structure that guides tail elongation, in elongating spermatids, and loss of Stk33 leads to the appearance of a tight, straight and elongated manchette.
      Title: Stk33 is required for spermatid differentiation and male fertility in mice.
    4. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity.
      Title: STK33 promotes hepatocellular carcinoma through binding to c-Myc.
    5. Double-immunostaining experiments with antibodies against Stk33 and vimentin showed a striking colocalization of Stk33 and vimentin in the hypothalamus.
      Title: Co-localization of serine/threonine kinase 33 (Stk33) and vimentin in the hypothalamus.
    6. STK33 promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells.
      Title: Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
    7. STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group
      Title: Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manchette assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 33
    NP_001342074.1
    NP_473444.1
    XP_006507287.1
    XP_006507288.1
    XP_006507289.1
    XP_006507291.1
    XP_006507292.1
    XP_011239951.1
    XP_011239952.1
    XP_011239954.1
    XP_017177431.1
    XP_017177432.1
    XP_030097864.1
    XP_030097865.1
    XP_036008474.1
    XP_036008475.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355145.1 → NP_001342074.1  serine/threonine-protein kinase 33 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124457, AC147221, AC165143
      Consensus CDS
      CCDS90306.1
      UniProtKB/TrEMBL
      A7E1Y3, D3YWA6
      Conserved Domains (1) summary
      cl21453
      Location:1 → 254
      PKc_like; Protein Kinases, catalytic domain

    2. NM_054103.1 → NP_473444.1  serine/threonine-protein kinase 33 isoform 1

      See identical proteins and their annotated locations for NP_473444.1

      Status: VALIDATED

      Source sequence(s)
      AK014819, AW061264, BB614724
      Consensus CDS
      CCDS52358.1
      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Related
      ENSMUSP00000102356.3, ENSMUST00000106745.9
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      108878270..109038375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507224.2 → XP_006507287.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_006507287.1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Related
      ENSMUSP00000112515.2, ENSMUST00000121748.8
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006507226.4 → XP_006507289.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_006507289.1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Related
      ENSMUSP00000087897.5, ENSMUST00000090414.11
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    3. XM_030242005.2 → XP_030097865.1  serine/threonine-protein kinase 33 isoform X5

      UniProtKB/TrEMBL
      A7E1Y3, D3YWA6
      Related
      ENSMUSP00000112560.2, ENSMUST00000121378.2
      Conserved Domains (1) summary
      cl21453
      Location:1 → 254
      PKc_like; Protein Kinases, catalytic domain

    4. XM_036152582.1 → XP_036008475.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030242004.1 → XP_030097864.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      A7E1Y3
      Conserved Domains (1) summary
      cl21453
      Location:72 → 340
      PKc_like; Protein Kinases, catalytic domain

    6. XM_011241652.2 → XP_011239954.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_011239954.1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    7. XM_006507228.4 → XP_006507291.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      A7E1Y3
      Conserved Domains (1) summary
      cl21453
      Location:72 → 340
      PKc_like; Protein Kinases, catalytic domain

    8. XM_017321942.2 → XP_017177431.1  serine/threonine-protein kinase 33 isoform X2

      UniProtKB/TrEMBL
      A7E1Y3
      Conserved Domains (1) summary
      cl21453
      Location:72 → 340
      PKc_like; Protein Kinases, catalytic domain

    9. XM_006507225.4 → XP_006507288.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_006507288.1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    10. XM_011241650.3 → XP_011239952.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_011239952.1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    11. XM_011241649.3 → XP_011239951.1  serine/threonine-protein kinase 33 isoform X1

      See identical proteins and their annotated locations for XP_011239951.1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    12. XM_036152581.1 → XP_036008474.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/Swiss-Prot
      Q4A1D4, Q924X7
      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    13. XM_017321943.2 → XP_017177432.1  serine/threonine-protein kinase 33 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:72 → 340
      PKc_like; Protein Kinases, catalytic domain

    14. XM_006507229.4 → XP_006507292.1  serine/threonine-protein kinase 33 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:109 → 377
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003946376.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924X7.2 GenPept UniProtKB/Swiss-Prot:Q924X7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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