Sipa1l3 signal-induced proliferation-associated 1 like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sipa1l3provided by MGI
Official Full Name: signal-induced proliferation-associated 1 like 3provided by MGI
Primary source: MGI:MGI:1921456
See related: Ensembl:ENSMUSG00000030583 AllianceGenome:MGI:1921456
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610511M17Rik
Summary: Predicted to enable GTPase activator activity. Involved in several processes, including epithelial cell morphogenesis; establishment of epithelial cell polarity; and eye development. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in several cellular components, including nucleoplasm; stress fiber; and tricellular tight junction. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens; lens anterior epithelium; lens fiber; lens vesicle; and lens vesicle anterior epithelium. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 17.0), small intestine adult (RPKM 16.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.94 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29016687..29218694, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (29320372..29519161, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To determine the impact of the truncated Sipa1l3 domains on eye development.
Title: A 16.7 kb deletion in Sipa1l3 is associated with juvenile cataract in mice.
Abnormalities of SIPA1L3 contribute to lens and eye defects, and we identify a critical role for SIPA1L3 in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization.
Title: Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Mit116 (e-PCR), detects polymorphism
- UniSTS:116708

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of epithelial cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic specialization, intracellular component	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info
located_in tricellular tight junction	ISO Inferred from Sequence Orthology more info
located_in tricellular tight junction	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: signal-induced proliferation-associated 1-like protein 3

Names: SIPA1-like protein 3; SPA-1-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081028.1 → NP_001074497.1 signal-induced proliferation-associated 1-like protein 3

See identical proteins and their annotated locations for NP_001074497.1

Status: PROVISIONAL

Source sequence(s)

AC164640, AC166079

Consensus CDS

CCDS39871.1

UniProtKB/Swiss-Prot

G3X9J0

Related

ENSMUSP00000082965.5, ENSMUST00000085809.11

Conserved Domains (4) summary

PHA03247
Location:1066 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

29016687..29218694 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250732.4 → XP_011249034.1 signal-induced proliferation-associated 1-like protein 3 isoform X3

See identical proteins and their annotated locations for XP_011249034.1

UniProtKB/Swiss-Prot

G3X9J0

Conserved Domains (4) summary

PHA03247
Location:1066 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540405.4 → XP_006540468.1 signal-induced proliferation-associated 1-like protein 3 isoform X4

Conserved Domains (4) summary

PHA03247
Location:1066 → 1705

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1720

SPAR_C; C-terminal domain of SPAR protein
XM_006540404.5 → XP_006540467.1 signal-induced proliferation-associated 1-like protein 3 isoform X2

Conserved Domains (4) summary

PHA03247
Location:1131 → 1705

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1720

SPAR_C; C-terminal domain of SPAR protein
XM_011250727.4 → XP_011249029.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_011249029.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_017312346.3 → XP_017167835.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540397.5 → XP_006540460.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006540460.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540402.3 → XP_006540465.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006540465.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540401.5 → XP_006540464.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006540464.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_011250729.4 → XP_011249031.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_011249031.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_011250730.4 → XP_011249032.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_011249032.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_011250731.4 → XP_011249033.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_011249033.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_011250728.4 → XP_011249030.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_011249030.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540400.4 → XP_006540463.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006540463.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540399.4 → XP_006540462.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006540462.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein
XM_006540403.3 → XP_006540466.1 signal-induced proliferation-associated 1-like protein 3 isoform X1

See identical proteins and their annotated locations for XP_006540466.1

Conserved Domains (4) summary

PHA03247
Location:1131 → 1706

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:960 → 1030

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02145
Location:635 → 815

Rap_GAP; Rap/ran-GAP

pfam11881
Location:1476 → 1721

SPAR_C; C-terminal domain of SPAR protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_028818.1: Suppressed sequence

Description

NM_028818.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.