Capg capping actin protein, gelsolin like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Capgprovided by MGI
Official Full Name: capping actin protein, gelsolin likeprovided by MGI
Primary source: MGI:MGI:1098259
See related: Ensembl:ENSMUSG00000056737 AllianceGenome:MGI:1098259
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mbh1; gCap39
Summary: Predicted to enable actin filament binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein domain specific binding activity. Acts upstream of or within cell projection assembly and cellular response to type II interferon. Located in phagocytic vesicle. Is expressed in several structures, including central nervous system; epithelium; forelimb; jaw; and metanephros. Orthologous to human CAPG (capping actin protein, gelsolin like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in genital fat pad adult (RPKM 25.9), bladder adult (RPKM 25.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.27 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (72515265..72539966)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (72538282..72562983)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Super-enhancer-associated gene CAPG promotes AML progression.
Title: Super-enhancer-associated gene CAPG promotes AML progression.
Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.
Title: Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498461 (e-PCR)
- UniSTS:498461

Capg (e-PCR), detects polymorphism
- UniSTS:498461

Capg (e-PCR), detects polymorphism
- UniSTS:498366

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament capping	IEA Inferred from Electronic Annotation more info
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell projection assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Flemming body	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: macrophage-capping protein

Names: actin regulatory protein CAP-G; actin-capping protein GCAP39; capping protein (actin filament), gelsolin-like; myc basic motif homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042534.3 → NP_001035999.1 macrophage-capping protein

See identical proteins and their annotated locations for NP_001035999.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AA289672, AK152818, AK165153, BY155308

Consensus CDS

CCDS39516.1

UniProtKB/TrEMBL

Q3UJ44, Q99LB4

Related

ENSMUSP00000109705.2, ENSMUST00000114071.8

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001271395.1 → NP_001258324.1 macrophage-capping protein

See identical proteins and their annotated locations for NP_001258324.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AC154002, AK152818, AK165153, CD551437

Consensus CDS

CCDS39516.1

UniProtKB/TrEMBL

Q3UJ44, Q99LB4

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_001271415.1 → NP_001258344.1 macrophage-capping protein

See identical proteins and their annotated locations for NP_001258344.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AC154002

Consensus CDS

CCDS39516.1

UniProtKB/TrEMBL

Q3UJ44, Q99LB4

Related

ENSMUSP00000109706.2, ENSMUST00000114072.8

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
NM_007599.4 → NP_031625.2 macrophage-capping protein

See identical proteins and their annotated locations for NP_031625.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK159577, AK165153, BU696808

Consensus CDS

CCDS39516.1

UniProtKB/TrEMBL

Q3UJ44, Q99LB4

Related

ENSMUSP00000063389.7, ENSMUST00000071044.13

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

72515265..72539966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321370.2 → XP_017176859.1 macrophage-capping protein isoform X1

UniProtKB/TrEMBL

Q3UJ44, Q99LB4

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins