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    Mtif3 mitochondrial translational initiation factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 76366, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mtif3provided by MGI
    Official Full Name
    mitochondrial translational initiation factor 3provided by MGI
    Primary source
    MGI:MGI:1923616
    See related
    Ensembl:ENSMUSG00000016510 AllianceGenome:MGI:1923616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810012L14Rik
    Summary
    Predicted to enable ribosomal small subunit binding activity and translation initiation factor activity. Predicted to be involved in mitochondrial translational initiation and ribosome disassembly. Predicted to be active in mitochondrion. Used to study dilated cardiomyopathy. Orthologous to human MTIF3 (mitochondrial translational initiation factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 7.4), CNS E18 (RPKM 6.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtif3 in Genome Data Viewer
    Location:
    5 G3; 5 86.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146888383..146900665, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146951573..146963855, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38748 Neighboring gene STARR-seq mESC enhancer starr_14856 Neighboring gene STARR-seq mESC enhancer starr_14857 Neighboring gene STARR-positive B cell enhancer mm9_chr5:147716001-147716302 Neighboring gene predicted gene 10858 Neighboring gene STARR-seq mESC enhancer starr_14858 Neighboring gene STARR-seq mESC enhancer starr_14860 Neighboring gene STARR-positive B cell enhancer ABC_E9268 Neighboring gene STARR-positive B cell enhancer ABC_E10366 Neighboring gene STARR-seq mESC enhancer starr_14863 Neighboring gene general transcription factor III A Neighboring gene STARR-seq mESC enhancer starr_14864 Neighboring gene predicted gene, 46936 Neighboring gene ligand of numb-protein X 2 Neighboring gene STARR-positive B cell enhancer ABC_E6405 Neighboring gene STARR-positive B cell enhancer ABC_E6406 Neighboring gene STARR-seq mESC enhancer starr_14866 Neighboring gene STARR-positive B cell enhancer ABC_E2184

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fidelity of translation initiation is required for coordinated respiratory complex assembly. Rudler DL, et al. Sci Adv, 2019 Dec. PMID 31903419, Free PMC Article
    2. Mitochondrial gene expression is required for platelet function and blood clotting. Richman TR, et al. Cell Rep, 2023 Nov 28. PMID 37889747
    3. Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. Koc EC, et al. J Biol Chem, 2002 Sep 20. PMID 12095986
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation factor activity, RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation factor activity, RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in ribosome disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation initiation factor IF-3, mitochondrial
    Names
    IF-3(Mt)
    IF-3Mt
    IF3(mt)
    IF3mt

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256100.1 → NP_001243029.1  translation initiation factor IF-3, mitochondrial

      See identical proteins and their annotated locations for NP_001243029.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AK012733, BC052439, BC115685, BM944410, BY284518
      Consensus CDS
      CCDS19874.1
      UniProtKB/Swiss-Prot
      Q14BP1, Q14BP2, Q9CZD5
      UniProtKB/TrEMBL
      A4QMQ0
      Related
      ENSMUSP00000106193.2, ENSMUST00000110564.8
      Conserved Domains (2) summary
      pfam05198
      Location:76 → 143
      IF3_N; Translation initiation factor IF-3, N-terminal domain
      cl27649
      Location:62 → 225
      IF3_C; Translation initiation factor IF-3, C-terminal domain

    2. NM_001256101.1 → NP_001243030.1  translation initiation factor IF-3, mitochondrial

      See identical proteins and their annotated locations for NP_001243030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AK012733, BC052439, BM944410, BY284518
      Consensus CDS
      CCDS19874.1
      UniProtKB/Swiss-Prot
      Q14BP1, Q14BP2, Q9CZD5
      UniProtKB/TrEMBL
      A4QMQ0
      Related
      ENSMUSP00000016654.3, ENSMUST00000016654.9
      Conserved Domains (2) summary
      pfam05198
      Location:76 → 143
      IF3_N; Translation initiation factor IF-3, N-terminal domain
      cl27649
      Location:62 → 225
      IF3_C; Translation initiation factor IF-3, C-terminal domain

    3. NM_001256102.1 → NP_001243031.1  translation initiation factor IF-3, mitochondrial

      See identical proteins and their annotated locations for NP_001243031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      BC052439, BC115684, BC115685, BM944410, BY284518
      Consensus CDS
      CCDS19874.1
      UniProtKB/Swiss-Prot
      Q14BP1, Q14BP2, Q9CZD5
      UniProtKB/TrEMBL
      A4QMQ0
      Related
      ENSMUSP00000106195.2, ENSMUST00000110566.2
      Conserved Domains (2) summary
      pfam05198
      Location:76 → 143
      IF3_N; Translation initiation factor IF-3, N-terminal domain
      cl27649
      Location:62 → 225
      IF3_C; Translation initiation factor IF-3, C-terminal domain

    4. NM_001359467.1 → NP_001346396.1  translation initiation factor IF-3, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AC124828, AL513345
      Consensus CDS
      CCDS19874.1
      UniProtKB/Swiss-Prot
      Q14BP1, Q14BP2, Q9CZD5
      UniProtKB/TrEMBL
      A4QMQ0
      Conserved Domains (2) summary
      pfam05198
      Location:76 → 143
      IF3_N; Translation initiation factor IF-3, N-terminal domain
      cl27649
      Location:62 → 225
      IF3_C; Translation initiation factor IF-3, C-terminal domain

    5. NM_029581.4 → NP_083857.1  translation initiation factor IF-3, mitochondrial

      See identical proteins and their annotated locations for NP_083857.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
      Source sequence(s)
      AK147090, BC052439, BM944410, BY284518
      Consensus CDS
      CCDS19874.1
      UniProtKB/Swiss-Prot
      Q14BP1, Q14BP2, Q9CZD5
      UniProtKB/TrEMBL
      A4QMQ0
      Related
      ENSMUSP00000063398.4, ENSMUST00000066675.10
      Conserved Domains (2) summary
      pfam05198
      Location:76 → 143
      IF3_N; Translation initiation factor IF-3, N-terminal domain
      cl27649
      Location:62 → 225
      IF3_C; Translation initiation factor IF-3, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      146888383..146900665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZD5.1 GenPept UniProtKB/Swiss-Prot:Q9CZD5

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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