Prok1 prokineticin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prok1provided by MGI
Official Full Name: prokineticin 1provided by MGI
Primary source: MGI:MGI:2180370
See related: Ensembl:ENSMUSG00000070368 AllianceGenome:MGI:2180370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG-VEGF
Summary: Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within positive regulation of MAPK cascade; positive regulation of vascular endothelial cell proliferation; and regulation of angiogenesis. Located in extracellular region. Is expressed in embryo; liver; lung; metanephros; and testis. Orthologous to human PROK1 (prokineticin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 8.2), kidney adult (RPKM 2.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 3 F2.3; 3 46.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (107139232..107147023, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (107231916..107239707, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical studies strongly suggested the potential involvement of the new angiogenic factor EG-VEGF in pregnancy-induced hypertension. Here is described the protocol that served to demonstrate that maintenance of EG-VEGF production over 11.5 days post coitus (dpc) in the gravid mice caused the development of pregnancy-induced hypertension.
Title: EG-VEGF Maintenance Over Early Gestation to Develop a Pregnancy-Induced Hypertensive Animal Model.
EG-VEGF is a new mediator of PPARgamma effects during pregnancy and bring new insights into the fine mechanism of trophoblast invasion.
Title: PPARγ controls pregnancy outcome through activation of EG-VEGF: new insights into the mechanism of placental development.
Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells.
Title: Prokineticin-1 (Prok-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells.
EG-VEGF was mainly localised in the labyrinth in mouse placenta. It may have direct effect on both endothelial & trophoblastic cells & is likely to play an important role in mouse placentation.
Title: Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.
plays a role in regulating the phenotype and growth properties of endothelial cells within distinct capillary beds
Title: Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis.
Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis
Title: The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.
This is the first report demonstrating that Prok-1 acts as a gut mucosa/mesenchyme-derived factor and maintains proliferation and differentiation of enteric neural crest cells.
Title: Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494979

Prok1 (e-PCR), detects polymorphism
- UniSTS:528631

Prok1 (e-PCR), detects polymorphism
- UniSTS:528632

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of vascular endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of vascular endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prokineticin-1

Names: endocrine-gland-derived vascular endothelial growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.