Tdpoz2 TD and POZ domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tdpoz2provided by MGI
Official Full Name: TD and POZ domain containing 2provided by MGI
Primary source: MGI:MGI:3027902
See related: Ensembl:ENSMUSG00000103362 AllianceGenome:MGI:3027902
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. Is expressed in brain and testis. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 3 F2.1; 3 40.51 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (93558849..93559993, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (93651542..93652686, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Tdpoz2 (e-PCR), detects polymorphism
- UniSTS:265755

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TD and POZ domain-containing protein 2

Names: TD and POZ domain containing gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007222.3 → NP_001007223.2 TD and POZ domain-containing protein 2

See identical proteins and their annotated locations for NP_001007223.2

Status: VALIDATED

Source sequence(s)

AC132362

Consensus CDS

CCDS57230.1

UniProtKB/Swiss-Prot

B2RUE5, E9QNP4, Q717B2

UniProtKB/TrEMBL

A0A0A6YVW8

Related

ENSMUSP00000141299.2, ENSMUST00000191960.2

Conserved Domains (4) summary

smart00225
Location:189 → 286

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14734
Location:287 → 349

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:178 → 284

BTB; BTB/POZ domain

cl02446
Location:16 → 153

MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...