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    Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 214084, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc18a2provided by MGI
    Official Full Name
    solute carrier family 18 (vesicular monoamine), member 2provided by MGI
    Primary source
    MGI:MGI:106677
    See related
    Ensembl:ENSMUSG00000025094 AllianceGenome:MGI:106677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vmat2; 9330105E13; 1110037L13Rik
    Summary
    Predicted to enable several functions, including amine transmembrane transporter activity; heat shock protein binding activity; and monoamine transmembrane transporter activity. Involved in histamine secretion by mast cell; neurotransmitter loading into synaptic vesicle; and serotonin secretion by mast cell. Acts upstream of or within several processes, including locomotory behavior; response to amphetamine; and response to toxic substance. Located in synaptic vesicle membrane. Is active in dopaminergic synapse. Is expressed in several structures, including adrenal gland; alimentary system; eye; integumental system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; infantile parkinsonism-dystonia 2; and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in ovary adult (RPKM 36.9), whole brain E14.5 (RPKM 10.7) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc18a2 in Genome Data Viewer
    Location:
    19 D3; 19 54.64 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59249310..59284444)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59260878..59296012)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930442E04 gene Neighboring gene potassium channel, subfamily K, member 18 Neighboring gene VISTA enhancer mm447 Neighboring gene PDZ domain containing 8 Neighboring gene ribosomal protein S12, pseudogene 3 Neighboring gene predicted gene, 50440

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC90556

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoamine:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serotonin:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aminergic neurotransmitter loading into synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aminergic neurotransmitter loading into synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histamine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurotransmitter loading into synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter loading into synaptic vesicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in serotonin secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in serotonin uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somato-dendritic dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in somato-dendritic dopamine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in dopaminergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal dense core vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    synaptic vesicular amine transporter
    Names
    VAT2
    monoamine transporter
    solute carrier family 18 member 2
    vesicular amine transporter 2
    vesicular monoamine transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172523.3NP_766111.1  synaptic vesicular amine transporter

      See identical proteins and their annotated locations for NP_766111.1

      Status: VALIDATED

      Source sequence(s)
      AC139040, AK033871, AK035644, AV328655
      Consensus CDS
      CCDS29935.1
      UniProtKB/Swiss-Prot
      Q8BRU6, Q8CC55
      Related
      ENSMUSP00000026084.4, ENSMUST00000026084.5
      Conserved Domains (3) summary
      cd06174
      Location:297474
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00880
      Location:135276
      2_A_01_02; Multidrug resistance protein
      pfam07690
      Location:133440
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      59249310..59284444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)