Kcnk18 potassium channel, subfamily K, member 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk18provided by MGI
Official Full Name: potassium channel, subfamily K, member 18provided by MGI
Primary source: MGI:MGI:2685627
See related: Ensembl:ENSMUSG00000040901 AllianceGenome:MGI:2685627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trik; Gm781; Tresk; Tresk-2
Summary: Enables calcium-activated potassium channel activity. Involved in potassium ion transport and regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Located in plasma membrane. Is expressed in gut; male reproductive gland or organ; and olfactory lobe. Human ortholog(s) of this gene implicated in migraine. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 19 D3; 19 54.63 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (59208080..59225802)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (59219648..59237370)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures.
Title: TRESK channel contributes to depolarization-induced shunting inhibition and modulates epileptic seizures.
TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage.
Title: TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage.
Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury.
Title: Upregulation of TRESK Channels Contributes to Motor and Sensory Recovery after Spinal Cord Injury.
TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
Title: TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons.
TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses.
Title: TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses.
Findings indicate that endogenous TWIK-related spinal cord K(+) (TRESK) activity regulates trigeminal nociception, likely through controlling the intrinsic excitability of trigeminal ganglia nociceptors.
Title: TRESK K(+) Channel Activity Regulates Trigeminal Nociception and Headache.
We compared the kinetics of Ba2+ block when channels were phosphorylated (inhibited) or dephosphorylated (activated) and in different mutants mimicking the two functional states. Neither the phosphorylation/dephosphorylation nor the point mutations influenced the development of Ba2+ block, suggesting that conformational changes of the bundle crossing region do not contribute to phosphorylation-dependent gating of TRESK.
Title: TRESK background potassium channel is not gated at the helix bundle crossing near the cytoplasmic end of the pore.
Migraine-associated TRESK mutation, but not the C110R variant, reduces the endogenous TRESK currents to a degree that affects trigeminal ganglion neuron excitability
Title: Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons.
Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies
Title: Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies.
a role for TRESK in the pathogenesis of typical migraine with aura.
Title: A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables outward rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info
enables outward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to pH	ISO Inferred from Sequence Orthology more info
involved_in potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in potassium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium channel subfamily K member 18

Names: 2P K ion channel TRESK; TWIK-related individual K+ channel; TWIK-related spinal cord K+ channel; two-pore-domain potassium channel TRESK

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.