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    Cyp4f15 cytochrome P450, family 4, subfamily f, polypeptide 15 [ Mus musculus (house mouse) ]

    Gene ID: 106648, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cyp4f15provided by MGI
    Official Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 15provided by MGI
    Primary source
    MGI:MGI:2146921
    See related
    Ensembl:ENSMUSG00000073424 AllianceGenome:MGI:2146921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp4f-15
    Summary
    Predicted to enable fatty acid binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and prostaglandin catabolic process. Predicted to be located in apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F11 (cytochrome P450 family 4 subfamily F member 11) and CYP4F2 (cytochrome P450 family 4 subfamily F member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 70.8), bladder adult (RPKM 60.4) and 4 other tissues See more
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    Genomic context

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    See Cyp4f15 in Genome Data Viewer
    Location:
    17 B1; 17 17.76 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32904605..32922329)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (32685631..32703352)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily f, member 38, pseudogene Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 40 Neighboring gene predicted gene, 53996 Neighboring gene non-SMC element 1 homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-tocopherol omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene-B4 20-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty acid omega-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene B4 catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukotriene B4 catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in omega-hydroxylase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 4, subfamily f, polypeptide 15
    Names
    cytochrome P450 CYP4F15
    cytochrome P450, 4f15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346538.1 → NP_001333467.1  cytochrome P450, family 4, subfamily f, polypeptide 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT033759, CT485613
      Consensus CDS
      CCDS84293.1
      UniProtKB/TrEMBL
      Q8VCA4
      Related
      ENSMUSP00000008801.7, ENSMUST00000008801.7

    2. NM_134127.1 → NP_598888.1  cytochrome P450, family 4, subfamily f, polypeptide 15 isoform 1

      See identical proteins and their annotated locations for NP_598888.1

      Status: VALIDATED

      Source sequence(s)
      AF233645
      Consensus CDS
      CCDS28620.1
      UniProtKB/TrEMBL
      Q99N18
      Related
      ENSMUSP00000129264.2, ENSMUST00000168171.8
      Conserved Domains (1) summary
      pfam00067
      Location:57 → 526
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      32904605..32922329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523412.3 → XP_006523475.1  cytochrome P450, family 4, subfamily f, polypeptide 15 isoform X1

      Conserved Domains (1) summary
      pfam00067
      Location:2 → 300
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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