C1ql1 complement component 1, q subcomponent-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1ql1provided by MGI
Official Full Name: complement component 1, q subcomponent-like 1provided by MGI
Primary source: MGI:MGI:1344400
See related: Ensembl:ENSMUSG00000045532 AllianceGenome:MGI:1344400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRF; Adil; C1qrf; CTRP14; gliacolin
Summary: Enables signaling receptor binding activity. Involved in regulation of synapse pruning. Acts upstream of or within maintenance of synapse structure; motor learning; and neuron remodeling. Located in climbing fiber; cytoplasm; and presynapse. Is active in cerebellar climbing fiber to Purkinje cell synapse and synaptic cleft. Is expressed in several structures, including brain; genitourinary system; gut; liver; and lung. Orthologous to human C1QL1 (complement C1q like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 41.8), frontal lobe adult (RPKM 6.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 66.48 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (102830090..102837542, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102939264..102946716, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding.
Title: CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding.
C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.
Title: C1ql1 is expressed in adult outer hair cells of the cochlea in a tonotopic gradient.
Signal transduction via C1qL1-BAI3 interaction is required for motor learning, triggers pruting of surplus cerebellar climbing fibers, and is required to maintain climbing fiber synapses.
Title: Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum.
Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1.
Title: Conserved recoding RNA editing of vertebrate C1q-related factor C1QL1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493109

NoName (e-PCR)
- UniSTS:490553

C1ql1 (e-PCR), detects polymorphism
- UniSTS:531286

C1ql1 (e-PCR), detects polymorphism
- UniSTS:531051

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within maintenance of synapse structure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within motor learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse pruning	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse pruning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar climbing fiber to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in climbing fiber	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C1q-related factor

Names: C1q and tumor necrosis factor-related protein 14; C1q/TNF-related protein 14; adiponectin l

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.