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    Nup88 nucleoporin 88 [ Mus musculus (house mouse) ]

    Gene ID: 19069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup88provided by MGI
    Official Full Name
    nucleoporin 88provided by MGI
    Primary source
    MGI:MGI:104900
    See related
    Ensembl:ENSMUSG00000040667 AllianceGenome:MGI:104900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nup84; Prei2
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nucleocytoplasmic transport. Predicted to be located in nuclear envelope and nucleoplasm. Predicted to be part of nuclear pore. Is expressed in central nervous system; early conceptus; gonad; and sensory organ. Human ortholog(s) of this gene implicated in fetal akinesia deformation sequence syndrome 4. Orthologous to human NUP88 (nucleoporin 88). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 33.6), CNS E14 (RPKM 26.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nup88 in Genome Data Viewer
    Location:
    11 B4; 11 43.21 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70833884..70860799, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70943058..70969973, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene ribosomal protein L23A, pseudogene 2 Neighboring gene predicted gene 12322 Neighboring gene STARR-seq mESC enhancer starr_29882 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70783671-70783780 Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH-box helicase 33 Neighboring gene predicted gene, 22297

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB. Takahashi N, et al. Biochem Biophys Res Commun, 2008 Sep 26. PMID 18621024
    2. Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus. Andres-Hernando A, et al. J Biol Chem, 2008 Sep 5. PMID 18606815, Free PMC Article
    3. Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons. Khalaf B, et al. J Cell Sci, 2019 Sep 26. PMID 31427429
    4. Expression patterns of novel genes during mouse preimplantation embryogenesis. Temeles GL, et al. Mol Reprod Dev, 1994 Feb. PMID 7545925
    5. Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. Naylor RM, et al. J Clin Invest, 2016 Feb. PMID 26731471, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes.
      Title: Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus.
    2. Nup88 regulates the activity of NF-kappaB at the level of nucleocytoplasmic transport.
      Title: Tumor marker nucleoporin 88 kDa regulates nucleocytoplasmic transport of NF-kappaB.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup88
    Names
    88 kDa nucleoporin
    preimplantation protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083331.2 → NP_001076800.1  nuclear pore complex protein Nup88 isoform 2

      See identical proteins and their annotated locations for NP_001076800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AK028563, AK050893, AK160619
      Consensus CDS
      CCDS36206.1
      UniProtKB/Swiss-Prot
      Q80Z13, Q8CEC0, Q8K090
      UniProtKB/TrEMBL
      Q3TM09
      Related
      ENSMUSP00000048101.5, ENSMUST00000035283.11
      Conserved Domains (2) summary
      pfam10168
      Location:14 → 751
      Nup88; Nuclear pore component
      pfam13863
      Location:570 → 678
      DUF4200; Domain of unknown function (DUF4200)

    2. NM_001276406.1 → NP_001263335.1  nuclear pore complex protein Nup88 isoform 3

      See identical proteins and their annotated locations for NP_001263335.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region, compared to variant 2. The encoded isoform (3) is shorter, compared to isoform 2.
      Source sequence(s)
      AK028563, AK050893, AK160619
      Consensus CDS
      CCDS70233.1
      UniProtKB/TrEMBL
      Q3TM09
      Related
      ENSMUSP00000104171.2, ENSMUST00000108531.8
      Conserved Domains (2) summary
      pfam10168
      Location:14 → 745
      Nup88; Nuclear pore component
      cl12013
      Location:589 → 688
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_172394.3 → NP_765982.2  nuclear pore complex protein Nup88 isoform 1

      See identical proteins and their annotated locations for NP_765982.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses two alternate splice sites in the coding region, compared to variant 2. The encoded isoform (1) is shorter, compared to isoform 2.
      Source sequence(s)
      AK050893, AK160619
      Consensus CDS
      CCDS36207.1
      UniProtKB/TrEMBL
      Q3TM09, Q5QNU0
      Related
      ENSMUSP00000104170.2, ENSMUST00000108530.2
      Conserved Domains (2) summary
      pfam10168
      Location:14 → 740
      Nup88; Nuclear pore component
      cl12013
      Location:584 → 683
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. NR_075087.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' exon structure, alternate splice sites in three internal exons, and lacks two internal exons, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK050893, AK139738, AK160619
      Related
      ENSMUST00000178253.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70833884..70860799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CEC0.1 GenPept UniProtKB/Swiss-Prot:Q8CEC0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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