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    Ccdc85a coiled-coil domain containing 85A [ Mus musculus (house mouse) ]

    Gene ID: 216613, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ccdc85aprovided by MGI
    Official Full Name
    coiled-coil domain containing 85Aprovided by MGI
    Primary source
    MGI:MGI:2445069
    See related
    Ensembl:ENSMUSG00000032878 AllianceGenome:MGI:2445069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in adherens junction. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CCDC85A (coiled-coil domain containing 85A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.5), frontal lobe adult (RPKM 3.1) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc85a in Genome Data Viewer
    Location:
    11 A3.3; 11 16.22 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (28335688..28537234, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (28385684..28587234, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28995 Neighboring gene STARR-seq mESC enhancer starr_28996 Neighboring gene STARR-seq mESC enhancer starr_28997 Neighboring gene predicted gene 12080 Neighboring gene STARR-seq mESC enhancer starr_28998 Neighboring gene STARR-seq mESC enhancer starr_28999 Neighboring gene STARR-seq mESC enhancer starr_29000 Neighboring gene STARR-seq mESC enhancer starr_29001 Neighboring gene STARR-seq mESC enhancer starr_29003 Neighboring gene STARR-seq mESC enhancer starr_29004 Neighboring gene STARR-seq mESC enhancer starr_29005 Neighboring gene STARR-seq mESC enhancer starr_29006 Neighboring gene cytochrome b5 domain containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29007 Neighboring gene STARR-seq mESC enhancer starr_29008 Neighboring gene STARR-seq mESC enhancer starr_29009 Neighboring gene STARR-seq mESC enhancer starr_29010 Neighboring gene STARR-seq mESC enhancer starr_29011 Neighboring gene RIKEN cDNA 2810471M01 gene Neighboring gene predicted gene, 34075 Neighboring gene microRNA 217 host gene Neighboring gene microRNA 216b Neighboring gene microRNA 216c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • E030025D05Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 85A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166661.3 → NP_001160133.1  coiled-coil domain-containing protein 85A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910
      Consensus CDS
      CCDS48760.1
      UniProtKB/Swiss-Prot
      Q5SP85
      Related
      ENSMUSP00000044649.9, ENSMUST00000042534.15
      Conserved Domains (1) summary
      pfam10226
      Location:29 → 202
      DUF2216; Uncharacterized conserved proteins (DUF2216)

    2. NM_001346759.2 → NP_001333688.1  coiled-coil domain-containing protein 85A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910
      Consensus CDS
      CCDS83786.1
      UniProtKB/TrEMBL
      E0CX32
      Related
      ENSMUSP00000124972.2, ENSMUST00000146385.9

    3. NM_001404024.1 → NP_001390953.1  coiled-coil domain-containing protein 85A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910

    4. NM_001404025.1 → NP_001390954.1  coiled-coil domain-containing protein 85A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910

    5. NM_001404026.1 → NP_001390955.1  coiled-coil domain-containing protein 85A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910

    6. NM_001404027.1 → NP_001390956.1  coiled-coil domain-containing protein 85A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910

    7. NM_181577.6 → NP_853555.2  coiled-coil domain-containing protein 85A isoform 1

      See identical proteins and their annotated locations for NP_853555.2

      Status: VALIDATED

      Source sequence(s)
      AL929280, BX255910
      Consensus CDS
      CCDS24489.1
      UniProtKB/Swiss-Prot
      Q5SP85, Q69Z68, Q6NZL9, Q8BGZ5, Q8BLC5, Q8VCC5
      Related
      ENSMUSP00000090941.4, ENSMUST00000093253.10
      Conserved Domains (1) summary
      pfam10226
      Location:29 → 202
      DUF2216; Uncharacterized conserved proteins (DUF2216)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      28335688..28537234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514657.5 → XP_006514720.1  coiled-coil domain-containing protein 85A isoform X3

      Conserved Domains (3) summary
      PHA03269
      Location:137 → 255
      PHA03269; envelope glycoprotein C; Provisional
      pfam10226
      Location:6 → 122
      CCDC85; CCDC85 family
      pfam15449
      Location:137 → 430
      Retinal; Retinal protein

    2. XM_011243694.3 → XP_011241996.1  coiled-coil domain-containing protein 85A isoform X7

      Conserved Domains (2) summary
      PHA03269
      Location:217 → 335
      PHA03269; envelope glycoprotein C; Provisional
      pfam10226
      Location:29 → 202
      CCDC85; CCDC85 family

    3. XM_036156536.1 → XP_036012429.1  coiled-coil domain-containing protein 85A isoform X4

      Conserved Domains (2) summary
      PHA03269
      Location:217 → 335
      PHA03269; envelope glycoprotein C; Provisional
      pfam10226
      Location:29 → 202
      CCDC85; CCDC85 family

    4. XM_036156537.1 → XP_036012430.1  coiled-coil domain-containing protein 85A isoform X5

      Conserved Domains (2) summary
      PHA03269
      Location:217 → 335
      PHA03269; envelope glycoprotein C; Provisional
      pfam10226
      Location:29 → 202
      CCDC85; CCDC85 family

    RNA

    1. XR_004936912.1 RNA Sequence

    2. XR_004936910.1 RNA Sequence

    3. XR_004936911.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001166662.1: Suppressed sequence

      Description
      NM_001166662.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SP85.1 GenPept UniProtKB/Swiss-Prot:Q5SP85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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