U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ints7 integrator complex subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 77065, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ints7provided by MGI
    Official Full Name
    integrator complex subunit 7provided by MGI
    Primary source
    MGI:MGI:1924315
    See related
    Ensembl:ENSMUSG00000037461 AllianceGenome:MGI:1924315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    int7; 5930412E23Rik
    Summary
    Predicted to be involved in DNA damage checkpoint signaling; cellular response to ionizing radiation; and snRNA 3'-end processing. Predicted to be located in chromosome; cytoplasm; and nuclear body. Predicted to be part of integrator complex. Is expressed in central nervous system and retina. Orthologous to human INTS7 (integrator complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 15.5), thymus adult (RPKM 13.6) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ints7 in Genome Data Viewer
    Location:
    1 H6; 1 96.51 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (191307652..191355802)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (191575540..191623690)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03433 Neighboring gene STARR-positive B cell enhancer ABC_E4408 Neighboring gene predicted gene, 32200 Neighboring gene predicted gene, 32334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:193343672-193343855 Neighboring gene STARR-positive B cell enhancer ABC_E803 Neighboring gene STARR-positive B cell enhancer ABC_E1579 Neighboring gene denticleless E3 ubiquitin protein ligase Neighboring gene STARR-positive B cell enhancer mm9_chr1:193423192-193423493 Neighboring gene STARR-seq mESC enhancer starr_03434 Neighboring gene predicted gene, 39741 Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene predicted gene, 22446

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7. Nakagawa H, et al. PLoS One, 2008 Jan 23. PMID 18213392, Free PMC Article
    2. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    3. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    integrator complex subunit 7

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306203.1 → NP_001293132.1  integrator complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001293132.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC132830, AK020029, AK052103, AK085336, AK086462, BP758668, CD348032, CK635124
      UniProtKB/Swiss-Prot
      Q7TQK1, Q8C3A9, Q8C3N4, Q8C3N6

    2. NM_001306204.1 → NP_001293133.1  integrator complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001293133.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
      Source sequence(s)
      AC132830, AK020029, AK052103, AK086462, BP758668, CD348032, CK635124
      UniProtKB/Swiss-Prot
      Q7TQK1, Q8C3A9, Q8C3N4, Q8C3N6

    3. NM_178632.6 → NP_848747.4  integrator complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_848747.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132830, AK020029, AK052103, AK086462, BP758668, CD348032, CK635124
      Consensus CDS
      CCDS35825.1
      UniProtKB/Swiss-Prot
      Q7TQK1, Q8C3A9, Q8C3N4, Q8C3N6
      UniProtKB/TrEMBL
      A0A0R4J0E4
      Related
      ENSMUSP00000036277.6, ENSMUST00000045450.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      191307652..191355802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_865812.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQK1.1 GenPept UniProtKB/Swiss-Prot:Q7TQK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous