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    Pfkl phosphofructokinase, liver, B-type [ Mus musculus (house mouse) ]

    Gene ID: 18641, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfklprovided by MGI
    Official Full Name
    phosphofructokinase, liver, B-typeprovided by MGI
    Primary source
    MGI:MGI:97547
    See related
    Ensembl:ENSMUSG00000020277 AllianceGenome:MGI:97547
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PFK-B; PFK-L; ATP-PFK
    Summary
    Enables 6-phosphofructokinase activity. Involved in glycolytic process through fructose-6-phosphate. Acts upstream of or within fructose 6-phosphate metabolic process; negative regulation of insulin secretion; and response to glucose. Located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Orthologous to human PFKL (phosphofructokinase, liver type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 59.9), ovary adult (RPKM 45.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pfkl in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77822781..77845641, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77986947..78009807, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 2 Neighboring gene predicted gene, 40705 Neighboring gene STARR-seq mESC enhancer starr_27210 Neighboring gene STARR-positive B cell enhancer ABC_E9033 Neighboring gene cilia and flagella associated protein 410 Neighboring gene STARR-positive B cell enhancer ABC_E5151 Neighboring gene STARR-seq mESC enhancer starr_27212 Neighboring gene STARR-seq mESC enhancer starr_27213 Neighboring gene STARR-seq mESC enhancer starr_27214 Neighboring gene STARR-seq mESC enhancer starr_27215 Neighboring gene autoimmune regulator Neighboring gene DNA methyltransferase 3-like Neighboring gene predicted gene, 51775 Neighboring gene icos ligand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 6-phosphofructokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to 6-phosphofructokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 6-phosphofructokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructose-6-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructose-6-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructose-6-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in canonical glycolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 1,6-bisphosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fructose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glycolytic process through fructose-6-phosphate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process through fructose-6-phosphate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process through fructose-6-phosphate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of 6-phosphofructokinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of 6-phosphofructokinase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of 6-phosphofructokinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ATP-dependent 6-phosphofructokinase, liver type
    Names
    6-phosphofructokinase type B
    6-phosphofructokinase, liver type
    phosphofructo-1-kinase isozyme B
    phosphofructokinase 1
    phosphohexokinase
    NP_001345722.1
    NP_032852.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358793.1NP_001345722.1  ATP-dependent 6-phosphofructokinase, liver type isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153507, AK030892, AK081313, BP766623, BY070321, EL605376
      UniProtKB/TrEMBL
      Q8CD98
      Conserved Domains (1) summary
      cl00204
      Location:1458
      PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. ...
    2. NM_008826.5NP_032852.2  ATP-dependent 6-phosphofructokinase, liver type isoform 1

      See identical proteins and their annotated locations for NP_032852.2

      Status: VALIDATED

      Source sequence(s)
      AK030892, AK081313, BP766623, BY070321
      Consensus CDS
      CCDS35955.1
      UniProtKB/Swiss-Prot
      P12382, Q8VDX7
      Related
      ENSMUSP00000020522.9, ENSMUST00000020522.9
      Conserved Domains (2) summary
      cd00764
      Location:13773
      Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
      TIGR02478
      Location:16755
      6PF1K_euk; 6-phosphofructokinase, eukaryotic type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77822781..77845641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)