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    Trpm2 transient receptor potential cation channel, subfamily M, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 28240, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trpm2provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 2provided by MGI
    Primary source
    MGI:MGI:1351901
    See related
    Ensembl:ENSMUSG00000009292 AllianceGenome:MGI:1351901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trp7; TRPC7; Trrp7; LTRPC2; 9830168K16Rik
    Summary
    Enables ligand-gated calcium channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; cellular response to temperature stimulus; and dendritic cell chemotaxis. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 10.5), cerebellum adult (RPKM 4.0) and 12 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trpm2 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77743556..77805746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77907722..77969909, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700009J07 gene Neighboring gene leucine rich repeat containing 3 Neighboring gene predicted gene, 53590 Neighboring gene predicted gene, 22394 Neighboring gene predicted gene, 22871 Neighboring gene predicted gene, 40705 Neighboring gene STARR-seq mESC enhancer starr_27210 Neighboring gene STARR-positive B cell enhancer ABC_E9033 Neighboring gene cilia and flagella associated protein 410 Neighboring gene phosphofructokinase, liver, B-type Neighboring gene STARR-positive B cell enhancer ABC_E5151

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables ADP-ribose diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT enables hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables intracellularly gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ligand-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ligand-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ligand-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligand-gated calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables manganese ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mono-ADP-D-ribose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mono-ADP-D-ribose binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoatomic cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in calcium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane import into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane import into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within manganese ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hydroperoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to purine-containing compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to purine-containing compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zinc ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily M member 2
    Names
    LTrpC-2
    long transient receptor potential channel 2
    transient receptor potential channel 7
    transient receptor protein 7
    NP_001398829.1
    NP_612174.2
    XP_006513793.1
    XP_006513794.1
    XP_006513795.1
    XP_006513796.1
    XP_011241772.1
    XP_017169449.1
    XP_017169451.1
    XP_036011694.1
    XP_036011695.1
    XP_036011696.1
    XP_036011697.1
    XP_036011698.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411900.1NP_001398829.1  transient receptor potential cation channel subfamily M member 2

      Status: VALIDATED

      Source sequence(s)
      AC153507, AC158612
      UniProtKB/Swiss-Prot
      Q5KTC0, Q91YD4
      Related
      ENSMUST00000105400.9
    2. NM_138301.2NP_612174.2  transient receptor potential cation channel subfamily M member 2

      See identical proteins and their annotated locations for NP_612174.2

      Status: VALIDATED

      Source sequence(s)
      AC153507, AC158612, AK036731, AK134735, AK136905, CJ108999
      Consensus CDS
      CCDS48611.1
      UniProtKB/Swiss-Prot
      Q5KTC0, Q91YD4
      Related
      ENSMUSP00000101040.3, ENSMUST00000105401.9
      Conserved Domains (4) summary
      TIGR00870
      Location:7161071
      trp; transient-receptor-potential calcium channel protein
      pfam00520
      Location:800976
      Ion_trans; Ion transport protein
      cl00447
      Location:13221502
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
      cl39032
      Location:140363
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      77743556..77805746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513731.5XP_006513794.1  transient receptor potential cation channel subfamily M member 2 isoform X3

      UniProtKB/TrEMBL
      Q3UYE9
      Conserved Domains (3) summary
      TIGR00870
      Location:189544
      trp; transient-receptor-potential calcium channel protein
      pfam00520
      Location:273421
      Ion_trans; Ion transport protein
      cl00447
      Location:795975
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    2. XM_006513732.2XP_006513795.1  transient receptor potential cation channel subfamily M member 2 isoform X4

      UniProtKB/TrEMBL
      Q3UYE9
      Conserved Domains (3) summary
      TIGR00870
      Location:185540
      trp; transient-receptor-potential calcium channel protein
      pfam00520
      Location:269417
      Ion_trans; Ion transport protein
      cl00447
      Location:791971
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    3. XM_036155801.1XP_036011694.1  transient receptor potential cation channel subfamily M member 2 isoform X7

      Conserved Domains (2) summary
      pfam00520
      Location:7123
      Ion_trans; Ion transport protein
      cl00447
      Location:469649
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    4. XM_017313962.2XP_017169451.1  transient receptor potential cation channel subfamily M member 2 isoform X10

      Conserved Domains (1) summary
      cl00447
      Location:47227
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    5. XM_036155803.1XP_036011696.1  transient receptor potential cation channel subfamily M member 2 isoform X9

      Conserved Domains (1) summary
      cl00447
      Location:73253
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    6. XM_036155804.1XP_036011697.1  transient receptor potential cation channel subfamily M member 2 isoform X10

      Conserved Domains (1) summary
      cl00447
      Location:47227
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    7. XM_017313960.2XP_017169449.1  transient receptor potential cation channel subfamily M member 2 isoform X7

      Conserved Domains (2) summary
      pfam00520
      Location:7123
      Ion_trans; Ion transport protein
      cl00447
      Location:469649
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    8. XM_036155805.1XP_036011698.1  transient receptor potential cation channel subfamily M member 2 isoform X10

      Conserved Domains (1) summary
      cl00447
      Location:47227
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    9. XM_036155802.1XP_036011695.1  transient receptor potential cation channel subfamily M member 2 isoform X8

      Conserved Domains (1) summary
      cl00447
      Location:168348
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    10. XM_006513730.3XP_006513793.1  transient receptor potential cation channel subfamily M member 2 isoform X2

      Conserved Domains (2) summary
      pfam00520
      Location:800948
      Ion_trans; Ion transport protein
      cl39032
      Location:140363
      LSDAT_euk; SLOG in TRPM
    11. XM_011243470.4XP_011241772.1  transient receptor potential cation channel subfamily M member 2 isoform X5

      Conserved Domains (1) summary
      cl39032
      Location:140363
      LSDAT_euk; SLOG in TRPM
    12. XM_006513733.5XP_006513796.1  transient receptor potential cation channel subfamily M member 2 isoform X6

      Conserved Domains (1) summary
      cl39032
      Location:140363
      LSDAT_euk; SLOG in TRPM

    RNA

    1. XR_004936198.1 RNA Sequence

    2. XR_001779532.1 RNA Sequence

    3. XR_004936196.1 RNA Sequence

    4. XR_871714.4 RNA Sequence