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    Cdk4 cyclin dependent kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 12567, updated on 4-Jan-2025

    Summary

    Official Symbol
    Cdk4provided by MGI
    Official Full Name
    cyclin dependent kinase 4provided by MGI
    Primary source
    MGI:MGI:88357
    See related
    Ensembl:ENSMUSG00000006728 AllianceGenome:MGI:88357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crk3
    Summary
    Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to ionomycin; cellular response to lipopolysaccharide; and cellular response to phorbol 13-acetate 12-myristate. Located in bicellular tight junction and nucleus. Part of cyclin D1-CDK4 complex; cyclin D2-CDK4 complex; and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; nervous system; sensory organ; and urinary system. Used to study skin melanoma and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 315.3), limb E14.5 (RPKM 224.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Cdk4 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126899404..126903157)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127063535..127067288)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126500339-126500526 Neighboring gene RIKEN cDNA A730063M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E582 Neighboring gene tetraspanin 31 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene amplified in osteosarcoma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Targeted (11)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables cyclin binding  
    enables cyclin binding PubMed 
    enables cyclin binding  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables kinase activity PubMed 
    enables protein binding PubMed 
    enables protein kinase activity PubMed 
    enables protein serine kinase activity  
    enables protein-containing complex binding  
    Items 1 - 25 of 31
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle PubMed 
    involved_in cell division  
    acts_upstream_of_or_within cellular response to interleukin-4 PubMed 
    acts_upstream_of_or_within cellular response to ionomycin PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within cellular response to phorbol 13-acetate 12-myristate PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of G2/M transition of mitotic cell cycle  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell size  
    involved_in positive regulation of epithelial cell proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of translation  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of G2/M transition of mitotic cell cycle  
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    involved_in regulation of cell cycle  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of gene expression  
    acts_upstream_of_or_within regulation of type B pancreatic cell proliferation PubMed 
    involved_in response to lead ion  
    involved_in response to testosterone  
    involved_in response to xenobiotic stimulus  
    involved_in signal transduction  
    acts_upstream_of_or_within signal transduction PubMed 
    Items 1 - 25 of 31
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in bicellular tight junction PubMed 
    located_in chromatin  
    located_in chromatin  
    part_of cyclin D1-CDK4 complex PubMed 
    part_of cyclin D1-CDK4 complex  
    part_of cyclin D2-CDK4 complex PubMed 
    part_of cyclin D2-CDK4 complex  
    part_of cyclin D3-CDK4 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex PubMed 
    part_of cyclin-dependent protein kinase holoenzyme complex  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  
    part_of transcription regulator complex PubMed 
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    cyclin-dependent kinase 4
    Names
    PSK-J3
    cell division protein kinase 4
    p34<PSK-J3>/cdk4
    serine/threonine kinase
    NP_001341934.1
    NP_034000.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355005.1NP_001341934.1  cyclin-dependent kinase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134329
      Conserved Domains (1) summary
      cl21453
      Location:1221
      PKc_like; Protein Kinases, catalytic domain
    2. NM_009870.4NP_034000.1  cyclin-dependent kinase 4 isoform 1

      See identical proteins and their annotated locations for NP_034000.1

      Status: VALIDATED

      Source sequence(s)
      AC134329
      Consensus CDS
      CCDS24226.1
      UniProtKB/Swiss-Prot
      P30285
      UniProtKB/TrEMBL
      Q545C3, Q8BP21, Q9D193
      Related
      ENSMUSP00000006911.6, ENSMUST00000006911.12
      Conserved Domains (1) summary
      cd07863
      Location:5295
      STKc_CDK4; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126899404..126903157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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