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    Wac WW domain containing adaptor with coiled-coil [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307029, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Wacprovided by RGD
    Official Full Name
    WW domain containing adaptor with coiled-coilprovided by RGD
    Primary source
    RGD:1562407
    See related
    EnsemblRapid:ENSRNOG00000018698 AllianceGenome:RGD:1562407
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562407
    Summary
    Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in several processes, including mitotic G1 DNA damage checkpoint signaling; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of macroautophagy. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Human ortholog(s) of this gene implicated in DeSanto-Shinawi syndrome. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 401.2), Lung (RPKM 347.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wac in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (60617702..60677771)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (55922686..55984286)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (60887606..60946630, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482777 Neighboring gene small Cajal body-specific RNA 20 Neighboring gene DEAD-box helicase 5, pseudogene 3 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Zhang F, et al. Mol Cell, 2011 Feb 18. PMID 21329877, Free PMC Article
    2. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Xu GM, et al. Genomics, 2002 Jan. PMID 11827461
    3. VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion. Totsukawa G, et al. EMBO J, 2011 Aug 2. PMID 21811234, Free PMC Article
    4. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. McKnight NC, et al. EMBO J, 2012 Apr 18. PMID 22354037, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WAC is hence thought to function in p97/p47-mediated Golgi membrane fusion by activating the deubiquitinating function of VCIP135.
      Title: VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-containing adapter protein with coiled-coil

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270417.1 → NP_001257346.1  WW domain-containing adapter protein with coiled-coil

      See identical proteins and their annotated locations for NP_001257346.1

      Status: PROVISIONAL

      Source sequence(s)
      AB574169
      UniProtKB/TrEMBL
      A6KPM9, F1LW69, G3XEV5
      Related
      ENSRNOP00000082342.2, ENSRNOT00000116963.2
      Conserved Domains (2) summary
      pfam00397
      Location:133 → 160
      WW; WW domain
      cl21494
      Location:423 → 528
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      60617702..60677771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276468.1 → XP_063132538.1  WW domain-containing adapter protein with coiled-coil isoform X7

    2. XM_039095733.2 → XP_038951661.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9
      Related
      ENSRNOP00000055641.6, ENSRNOT00000058852.6
      Conserved Domains (3) summary
      PHA03247
      Location:172 → 490
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:86 → 153
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:88 → 115
      WW; WW domain

    3. XM_063276466.1 → XP_063132536.1  WW domain-containing adapter protein with coiled-coil isoform X6

    4. XM_063276472.1 → XP_063132542.1  WW domain-containing adapter protein with coiled-coil isoform X11

    5. XM_063276467.1 → XP_063132537.1  WW domain-containing adapter protein with coiled-coil isoform X7

    6. XM_039095730.2 → XP_038951658.1  WW domain-containing adapter protein with coiled-coil isoform X3

      UniProtKB/TrEMBL
      A6KPM9
      Conserved Domains (3) summary
      PHA03247
      Location:217 → 535
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:131 → 198
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:133 → 160
      WW; WW domain

    7. XM_039095738.2 → XP_038951666.1  WW domain-containing adapter protein with coiled-coil isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZWU8, A6KPM9
      Conserved Domains (3) summary
      PHA03247
      Location:195 → 425
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:131 → 198
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:133 → 160
      WW; WW domain

    8. XM_063276462.1 → XP_063132532.1  WW domain-containing adapter protein with coiled-coil isoform X1

    9. XM_063276463.1 → XP_063132533.1  WW domain-containing adapter protein with coiled-coil isoform X2

    10. XM_063276464.1 → XP_063132534.1  WW domain-containing adapter protein with coiled-coil isoform X4

    11. XM_063276465.1 → XP_063132535.1  WW domain-containing adapter protein with coiled-coil isoform X5

    12. XM_063276471.1 → XP_063132541.1  WW domain-containing adapter protein with coiled-coil isoform X9

    13. XM_063276470.1 → XP_063132540.1  WW domain-containing adapter protein with coiled-coil isoform X8

    14. XM_063276473.1 → XP_063132543.1  WW domain-containing adapter protein with coiled-coil isoform X12

      Related
      ENSRNOP00000110310.1, ENSRNOT00000100553.2

    15. XM_039095734.2 → XP_038951662.1  WW domain-containing adapter protein with coiled-coil isoform X7

      UniProtKB/TrEMBL
      A6KPM9
      Conserved Domains (3) summary
      PHA03247
      Location:172 → 490
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:86 → 153
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:88 → 115
      WW; WW domain

    16. XM_063276469.1 → XP_063132539.1  WW domain-containing adapter protein with coiled-coil isoform X7

    RNA

    1. XR_010058876.1 RNA Sequence

    2. XR_010058875.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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