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    Svil supervillin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Svilprovided by RGD
    Official Full Name
    supervillinprovided by RGD
    Primary source
    RGD:1306354
    See related
    EnsemblRapid:ENSRNOG00000018110 AllianceGenome:RGD:1306354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within muscle cell differentiation. Predicted to be located in several cellular components, including costamere; focal adhesion; and sarcolemma. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 505.9), Heart (RPKM 236.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Svil in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (57343910..57539508, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (52648502..52844114, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (55230298..55425967, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 438 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 3 Neighboring gene uncharacterized LOC108348573 Neighboring gene uncharacterized LOC120097826 Neighboring gene ribosomal protein S24, pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. Oh SW, et al. J Cell Sci, 2003 Jun 1. PMID 12711699
    2. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    3. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
    4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    supervillin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108416.3 → NP_001101886.2  supervillin

      See identical proteins and their annotated locations for NP_001101886.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6A8S3, F1M155
      Related
      ENSRNOP00000025037.7, ENSRNOT00000025037.10
      Conserved Domains (6) summary
      smart00153
      Location:2130 → 2165
      VHP; Villin headpiece domain
      cd11280
      Location:1514 → 1614
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1830 → 1935
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1393 → 1489
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1697 → 1810
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1952 → 2074
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      57343910..57539508 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254030.5 → XP_006254092.1  supervillin isoform X8

      See identical proteins and their annotated locations for XP_006254092.1

      UniProtKB/TrEMBL
      A0A8I6A8S3
      Conserved Domains (6) summary
      smart00153
      Location:2173 → 2208
      VHP; Villin headpiece domain
      cd11280
      Location:1557 → 1657
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1873 → 1978
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1436 → 1532
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1740 → 1853
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1995 → 2117
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    2. XM_063276626.1 → XP_063132696.1  supervillin isoform X8

      UniProtKB/TrEMBL
      A0A8I6A8S3

    3. XM_006254031.5 → XP_006254093.1  supervillin isoform X8

      See identical proteins and their annotated locations for XP_006254093.1

      UniProtKB/TrEMBL
      A0A8I6A8S3
      Conserved Domains (6) summary
      smart00153
      Location:2173 → 2208
      VHP; Villin headpiece domain
      cd11280
      Location:1557 → 1657
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1873 → 1978
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1436 → 1532
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1740 → 1853
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1995 → 2117
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    4. XM_017600627.3 → XP_017456116.1  supervillin isoform X18

      UniProtKB/TrEMBL
      A0A8I6AHH0, D3ZEZ9
      Related
      ENSRNOP00000092895.1, ENSRNOT00000095281.2
      Conserved Domains (6) summary
      smart00153
      Location:1731 → 1766
      VHP; Villin headpiece domain
      cd11280
      Location:1115 → 1215
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1431 → 1536
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:994 → 1090
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1298 → 1411
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1553 → 1675
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    5. XM_063276628.1 → XP_063132698.1  supervillin isoform X16

      UniProtKB/TrEMBL
      D3ZEZ9

    6. XM_017600626.3 → XP_017456115.1  supervillin isoform X17

      UniProtKB/TrEMBL
      D3ZEZ9

    7. XM_017600625.3 → XP_017456114.1  supervillin isoform X15

      UniProtKB/TrEMBL
      D3ZEZ9
      Conserved Domains (6) summary
      smart00153
      Location:1805 → 1840
      VHP; Villin headpiece domain
      cd11280
      Location:1189 → 1289
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1505 → 1610
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1068 → 1164
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1372 → 1485
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1627 → 1749
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    8. XM_039095919.2 → XP_038951847.1  supervillin isoform X14

      UniProtKB/TrEMBL
      D3ZEZ9
      Conserved Domains (6) summary
      smart00153
      Location:1832 → 1867
      VHP; Villin headpiece domain
      cd11280
      Location:1216 → 1316
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1532 → 1637
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1095 → 1191
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1399 → 1512
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1654 → 1776
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    9. XM_017600623.3 → XP_017456112.1  supervillin isoform X12

      UniProtKB/TrEMBL
      D3ZEZ9

    10. XM_039095918.2 → XP_038951846.1  supervillin isoform X11

      UniProtKB/TrEMBL
      D3ZEZ9
      Conserved Domains (6) summary
      smart00153
      Location:1887 → 1922
      VHP; Villin headpiece domain
      cd11280
      Location:1271 → 1371
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1587 → 1692
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1150 → 1246
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1454 → 1567
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1709 → 1831
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    11. XM_017600615.3 → XP_017456104.1  supervillin isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8S3, A0A8I6AVE6
      Related
      ENSRNOP00000097742.2, ENSRNOT00000117999.2
      Conserved Domains (6) summary
      smart00153
      Location:2172 → 2207
      VHP; Villin headpiece domain
      cd11280
      Location:1556 → 1656
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1872 → 1977
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1435 → 1531
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1739 → 1852
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1994 → 2116
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    12. XM_017600624.3 → XP_017456113.1  supervillin isoform X13

      UniProtKB/TrEMBL
      D3ZEZ9
      Conserved Domains (6) summary
      smart00153
      Location:1833 → 1868
      VHP; Villin headpiece domain
      cd11280
      Location:1217 → 1317
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1533 → 1638
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1096 → 1192
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1400 → 1513
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1655 → 1777
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    13. XM_017600621.3 → XP_017456110.1  supervillin isoform X10

      UniProtKB/TrEMBL
      D3ZEZ9
      Related
      ENSRNOP00000062712.4, ENSRNOT00000064331.6

    14. XM_063276627.1 → XP_063132697.1  supervillin isoform X9

      UniProtKB/TrEMBL
      A0A8I6AQK9
      Related
      ENSRNOP00000081911.2, ENSRNOT00000108405.2

    15. XM_063276625.1 → XP_063132695.1  supervillin isoform X7

      UniProtKB/TrEMBL
      A0A8I6AQK9

    16. XM_017600619.3 → XP_017456108.1  supervillin isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKD0
      Conserved Domains (6) summary
      smart00153
      Location:2118 → 2153
      VHP; Villin headpiece domain
      cd11280
      Location:1502 → 1602
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1818 → 1923
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1381 → 1477
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1685 → 1798
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1940 → 2062
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    17. XM_063276624.1 → XP_063132694.1  supervillin isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZT25, A0A8I6A8S3

    18. XM_017600617.3 → XP_017456106.1  supervillin isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8S3
      Conserved Domains (6) summary
      smart00153
      Location:2141 → 2176
      VHP; Villin headpiece domain
      cd11280
      Location:1525 → 1625
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1841 → 1946
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1404 → 1500
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1708 → 1821
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1963 → 2085
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    19. XM_017600618.3 → XP_017456107.1  supervillin isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8S3
      Related
      ENSRNOP00000088108.1, ENSRNOT00000100582.2
      Conserved Domains (6) summary
      smart00153
      Location:2131 → 2166
      VHP; Villin headpiece domain
      cd11280
      Location:1515 → 1615
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1831 → 1936
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1394 → 1490
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1698 → 1811
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1953 → 2075
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    20. XM_017600616.3 → XP_017456105.1  supervillin isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8S3
      Conserved Domains (6) summary
      smart00153
      Location:2147 → 2182
      VHP; Villin headpiece domain
      cd11280
      Location:1531 → 1631
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1847 → 1952
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:1410 → 1506
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:1714 → 1827
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1969 → 2091
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein Strain
    Heading Accession and Version

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