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    Dok5 docking protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502694, updated on 27-Dec-2024

    Summary

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    Symbol
    Dok5provided by RGD
    Full Name
    docking protein 5provided by RGD
    Primary source
    RGD:1562846
    See related
    EnsemblRapid:ENSRNOG00000013196 AllianceGenome:RGD:1562846
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562846
    Summary
    Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within neuron differentiation; positive regulation of MAPK cascade; and regulation of neurotrophin TRK receptor signaling pathway. Predicted to be active in cytoplasm. Orthologous to human DOK5 (docking protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 52.9), Brain (RPKM 48.3) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dok5 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (179934419..180071334)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (159515886..159652811)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (168345116..168482445)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101807 Neighboring gene uncharacterized LOC120101808 Neighboring gene uncharacterized LOC120101806 Neighboring gene uncharacterized LOC134486495 Neighboring gene uncharacterized LOC102552784 Neighboring gene uncharacterized LOC108350532

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Pan Y, et al. Neurosci Lett, 2013 Oct 11. PMID 23954828
    2. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. Grimm J, et al. J Cell Biol, 2001 Jul 23. PMID 11470823, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    docking protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109344.2 → NP_001102814.1  docking protein 5

      See identical proteins and their annotated locations for NP_001102814.1

      Status: PROVISIONAL

      Source sequence(s)
      BC167027
      UniProtKB/TrEMBL
      A0A8I6A882, A0A9K3Y7G0, B2RZ51, F1LMM0
      Related
      ENSRNOP00000017654.6, ENSRNOT00000017654.9
      Conserved Domains (3) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
      pfam00169
      Location:8 → 111
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      179934419..180071334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235673.5 → XP_006235735.1  docking protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A7S1, A0A8I6AWK3
      Conserved Domains (3) summary
      cd13164
      Location:133 → 235
      PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
      cd14678
      Location:9 → 113
      PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
      pfam00169
      Location:8 → 111
      PH; PH domain

    2. XM_063284407.1 → XP_063140477.1  docking protein 5 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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