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    Tube1 tubulin, epsilon 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361856, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tube1provided by RGD
    Official Full Name
    tubulin, epsilon 1provided by RGD
    Primary source
    RGD:1306048
    See related
    EnsemblRapid:ENSRNOG00000000598 AllianceGenome:RGD:1306048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Orthologous to human TUBE1 (tubulin epsilon 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 128.0), Spleen (RPKM 28.8) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tube1 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (44105405..44124947)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (42552390..42570324)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44220823..44238830)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene laminin subunit alpha 4 Neighboring gene M-phase phosphoprotein 6-like Neighboring gene uncharacterized LOC120098941 Neighboring gene family with sequence similarity 229, member B Neighboring gene uncharacterized LOC108349081 Neighboring gene cellular communication network factor 6 Neighboring gene claudin-7 pseudogene Neighboring gene FYN proto-oncogene, Src family tyrosine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tubulin epsilon chain
    Names
    epsilon-tubulin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399016.1NP_001385945.1  tubulin epsilon chain

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6KIF3
      Related
      ENSRNOP00000044143.5, ENSRNOT00000047194.5
      Conserved Domains (1) summary
      cd02190
      Location:2457
      epsilon_tubulin; The epsilon-tubulin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      44105405..44124947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256529.3XP_006256591.1  tubulin epsilon chain isoform X1

      UniProtKB/TrEMBL
      A6KIF6
      Conserved Domains (1) summary
      cd02190
      Location:1382
      epsilon_tubulin; The epsilon-tubulin family

    RNA

    1. XR_010060729.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108536.1: Suppressed sequence

      Description
      NM_001108536.1: This RefSeq was removed because currently there is insufficient support for the transcript.