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    Tmem240 transmembrane protein 240 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362471, updated on 2-Nov-2024

    Summary

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    Symbol
    Tmem240provided by RGD
    Full Name
    transmembrane protein 240provided by RGD
    Primary source
    RGD:2318117
    See related
    EnsemblRapid:ENSRNOG00000066137 AllianceGenome:RGD:2318117
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in TMEM240-body. Predicted to be active in cerebellar climbing fiber to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 21. Orthologous to human TMEM240 (transmembrane protein 240). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 55.0), Thymus (RPKM 16.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem240 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171625830..171653836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166344000..166350210)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173182815..173189683)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 10 Neighboring gene SSU72 homolog, RNA polymerase II CTD phosphatase Neighboring gene U6 spliceosomal RNA Neighboring gene ATPase family, AAA domain containing 3A Neighboring gene ATPase family, AAA domain containing 3A, opposite strand Neighboring gene von Willebrand factor A domain containing 1 Neighboring gene transmembrane protein 88B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Trinidad JC, et al. Mol Cell Proteomics, 2012 Aug. PMID 22645316, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in TMEM240-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cerebellar climbing fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 240

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171625830..171653836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002729582.7 → XP_002729628.4  transmembrane protein 240 isoform X1

      Related
      ENSRNOP00000063372.2, ENSRNOT00000068062.3
      Conserved Domains (1) summary
      pfam15207
      Location:158 → 330
      TMEM240; TMEM240 family

    2. XM_008764408.4 → XP_008762630.2  transmembrane protein 240 isoform X2

      Conserved Domains (1) summary
      pfam15207
      Location:158 → 212
      TMEM240; TMEM240 family

    3. XM_063288670.1 → XP_063144740.1  transmembrane protein 240 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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