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    Crem cAMP responsive element modulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25620, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cremprovided by RGD
    Official Full Name
    cAMP responsive element modulatorprovided by RGD
    Primary source
    RGD:2402
    See related
    EnsemblRapid:ENSRNOG00000014900 AllianceGenome:RGD:2402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Icer
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in fatty acid metabolic process; glucose metabolic process; and retinoic acid receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Biomarker of transient cerebral ischemia. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 90.5), Testes (RPKM 74.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crem in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58932011..59001160)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54238889..54305989)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (57021704..57090888)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930596D02 gene like 2 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene cullin 2 Neighboring gene uncharacterized LOC108348578 Neighboring gene Histone deacetylase 1, pseudogene 12 Neighboring gene marker of proliferation Ki-67, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Steinbicker AU, et al. Nitric Oxide, 2011 Oct 30. PMID 21642009, Free PMC Article
    2. Inducible cAMP early repressor suppresses gastrin-mediated activation of cyclin D1 and c-fos gene expression. Steigedal TS, et al. Am J Physiol Gastrointest Liver Physiol, 2007 Apr. PMID 17185632
    3. Yukmijihwang-tang protects against cyclophosphamide-induced reproductive toxicity. Oh MS, et al. Reprod Toxicol, 2007 Nov-Dec. PMID 17624719
    4. Role of cAMP-responsive element modulator-tau (CREMtau) in ipsilateral testicular injury after unilateral testicular torsion-detorsion. Wei SM, et al. Fertil Steril, 2008 Jun. PMID 17681298
    5. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Ding B, et al. Proc Natl Acad Sci U S A, 2005 Oct 11. PMID 16186489, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression levels of ICER and BDNF were increased remarkably but the GABAA R alpha1 subunit decreased significantly in the drug-resistant epileptic rats. However, the expression levels of ICER, BDNF were decreased and the expression of the GABAA R alpha1 subunit increased significantly in the drug-resistant epileptic rats after two weeks of Hip-LFS.
      Title: Influence of hippocampal low-frequency stimulation on GABA(A) R α1, ICER and BNDF expression level in brain tissues of amygdala-kindled drug-resistant temporal lobe epileptic rats.
    2. Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleus accumbens core.
      Title: Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.
    3. These data suggest that fluoride can impair male reproduction by affecting expression of P450, CREM, and ACT in the testes.
      Title: Effects of Fluoride on Expression of P450, CREM and ACT Proteins in Rat Testes.
    4. The ERK1/2 and ICER-mediated feed forward loop is the hidden design principle underlying the switching role of beta-adrenergic receptor signaling in cell survival or death decision of cardiomyocytes.
      Title: The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.
    5. CREM/ICER is a negative regulator of endothelial function
      Title: Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
    6. Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1gamma.
      Title: Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.
    7. CREM-1 may play an important role in regulating neuronal death after traumatic brain injury by interacting with cyclic AMP response element-binding protein (CREB).
      Title: Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain injury.
    8. The induction of ICER in GSNO-treated RPaSMC highlights a novel cross-talk mechanism between cGMP and cAMP signaling pathways.
      Title: Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene.
    9. we have found that silencing of ICERs enhances the CRE-driven transcription and exerts a mild, although significant, neuroprotective effect
      Title: Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from programmed cell death.
    10. Induction of ICER links oxidative stress to beta cell failure caused by oxidised LDL, and it can be effectively abrogated by antioxidant treatment.
      Title: Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glucose metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glycosphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-responsive element modulator
    Names
    CRE modulator
    cAMP responsive element moderator
    inducible cyclic AMP early repressor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110860.2 → NP_001104330.1  cAMP-responsive element modulator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 3.
      Source sequence(s)
      BC078899, JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A140TAC1, A6K9H0
      Related
      ENSRNOP00000090155.2, ENSRNOT00000115950.2
      Conserved Domains (2) summary
      cd14690
      Location:301 → 355
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    2. NM_001271101.1 → NP_001258030.1  cAMP-responsive element modulator isoform 4

      See identical proteins and their annotated locations for NP_001258030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, compared to variant 3. This results in protein (isoform 4) that is the same length but has a distinct C-terminus, compared to isoform 3.
      Source sequence(s)
      BC078899, JAXUCZ010000017
      UniProtKB/Swiss-Prot
      Q03061, Q6AYV1
      UniProtKB/TrEMBL
      A0A8I6ACV8
      Conserved Domains (2) summary
      cd14690
      Location:301 → 355
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:112 → 151
      pKID; pKID domain

    3. NM_001271102.1 → NP_001258031.1  cAMP-responsive element modulator isoform 5

      See identical proteins and their annotated locations for NP_001258031.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in 5' UTR and 5' coding region, compared to variant 3. This results in a protein (isoform 5) that is shorter and has a distinct N-terminus compared to isoform 3.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:57 → 111
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001271245.1 → NP_001258174.1  cAMP-responsive element modulator isoform 6

      See identical proteins and their annotated locations for NP_001258174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform 6) that is shorter at both the N- and C-termini, compared to isoform 3.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6K9H5, Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:63 → 117
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    5. NM_001271246.1 → NP_001258175.1  cAMP-responsive element modulator isoform 7

      See identical proteins and their annotated locations for NP_001258175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in 5' UTR and 5' coding region, compared to variant 3. This results in a protein (isoform 7) that has a shorter N-terminus compared to isoform 3.
      Source sequence(s)
      FM089481, JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A0G2K748, A6K9H6, Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    6. NM_001271247.1 → NP_001258176.1  cAMP-responsive element modulator isoform 8

      See identical proteins and their annotated locations for NP_001258176.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in 5' UTR and 5' coding region, compared to variant 3. This results in a protein (isoform 8) that has a shorter N-terminus compared to isoform 3.
      Source sequence(s)
      FM033648, JAXUCZ010000017
      UniProtKB/TrEMBL
      Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:63 → 117
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    7. NM_001271248.1 → NP_001258177.1  cAMP-responsive element modulator isoform 9

      See identical proteins and their annotated locations for NP_001258177.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform 9) that is shorter at both the N- and C-termini, compared to isoform 3.
      Source sequence(s)
      CO556486, JAXUCZ010000017
      UniProtKB/TrEMBL
      A6K9H7, Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    8. NM_017334.2 → NP_059030.2  cAMP-responsive element modulator isoform 2

      See identical proteins and their annotated locations for NP_059030.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform 2) that is shorter at both the N- and C-termini, compared to isoform 3.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6K9H3
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      58932011..59001160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276102.1 → XP_063132172.1  cAMP-responsive element modulator isoform X29

    2. XM_063276103.1 → XP_063132173.1  cAMP-responsive element modulator isoform X30

    3. XM_063276105.1 → XP_063132175.1  cAMP-responsive element modulator isoform X33

    4. XM_039095385.2 → XP_038951313.1  cAMP-responsive element modulator isoform X36

      UniProtKB/TrEMBL
      Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    5. XM_006254051.5 → XP_006254113.1  cAMP-responsive element modulator isoform X4

      UniProtKB/TrEMBL
      A6K9H0
      Conserved Domains (2) summary
      cd14690
      Location:285 → 339
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:96 → 135
      pKID; pKID domain

    6. XM_039095381.2 → XP_038951309.1  cAMP-responsive element modulator isoform X13

      UniProtKB/TrEMBL
      A6K9H0
      Conserved Domains (2) summary
      cd14690
      Location:236 → 290
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:47 → 86
      pKID; pKID domain

    7. XM_063276081.1 → XP_063132151.1  cAMP-responsive element modulator isoform X1

      UniProtKB/TrEMBL
      A0A140TAC1

    8. XM_063276083.1 → XP_063132153.1  cAMP-responsive element modulator isoform X3

      Related
      ENSRNOP00000083222.2, ENSRNOT00000111611.2

    9. XM_063276090.1 → XP_063132160.1  cAMP-responsive element modulator isoform X12

      UniProtKB/TrEMBL
      A0A0G2JYV9
      Related
      ENSRNOP00000070810.2, ENSRNOT00000092187.3

    10. XM_063276092.1 → XP_063132162.1  cAMP-responsive element modulator isoform X15

    11. XM_063276085.1 → XP_063132155.1  cAMP-responsive element modulator isoform X6

      UniProtKB/TrEMBL
      A0A8L2QUF6
      Related
      ENSRNOP00000062109.3, ENSRNOT00000068545.5

    12. XM_063276086.1 → XP_063132156.1  cAMP-responsive element modulator isoform X7

    13. XM_063276089.1 → XP_063132159.1  cAMP-responsive element modulator isoform X11

    14. XM_063276095.1 → XP_063132165.1  cAMP-responsive element modulator isoform X21

    15. XM_063276096.1 → XP_063132166.1  cAMP-responsive element modulator isoform X22

    16. XM_063276099.1 → XP_063132169.1  cAMP-responsive element modulator isoform X25

    17. XM_063276082.1 → XP_063132152.1  cAMP-responsive element modulator isoform X2

      Related
      ENSRNOP00000089944.2, ENSRNOT00000112412.2

    18. XM_063276091.1 → XP_063132161.1  cAMP-responsive element modulator isoform X14

      UniProtKB/TrEMBL
      A0A140TAC0
      Related
      ENSRNOP00000020160.8, ENSRNOT00000020160.10

    19. XM_063276088.1 → XP_063132158.1  cAMP-responsive element modulator isoform X10

    20. XM_063276098.1 → XP_063132168.1  cAMP-responsive element modulator isoform X24

    21. XM_063276093.1 → XP_063132163.1  cAMP-responsive element modulator isoform X18

    22. XM_039095386.2 → XP_038951314.1  cAMP-responsive element modulator isoform X36

      UniProtKB/TrEMBL
      Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    23. XM_008771692.3 → XP_008769914.1  cAMP-responsive element modulator isoform X35

      See identical proteins and their annotated locations for XP_008769914.1

      UniProtKB/TrEMBL
      A0A0G2K748, A6K9H6, Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    24. XM_063276084.1 → XP_063132154.1  cAMP-responsive element modulator isoform X5

    25. XM_006254061.5 → XP_006254123.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      A0A8I5ZW07, D3ZXY8
      Related
      ENSRNOP00000083169.1, ENSRNOT00000096686.2
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    26. XM_006254062.5 → XP_006254124.1  cAMP-responsive element modulator isoform X19

      UniProtKB/TrEMBL
      D3ZXY8
      Conserved Domains (2) summary
      cd14690
      Location:212 → 266
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    27. XM_006254068.5 → XP_006254130.1  cAMP-responsive element modulator isoform X27

      Conserved Domains (2) summary
      cd14690
      Location:149 → 203
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    28. XM_063276100.1 → XP_063132170.1  cAMP-responsive element modulator isoform X26

    29. XM_006254060.5 → XP_006254122.1  cAMP-responsive element modulator isoform X16

      UniProtKB/TrEMBL
      D3ZXY8
      Related
      ENSRNOP00000074062.3, ENSRNOT00000089536.3
      Conserved Domains (2) summary
      cd14690
      Location:224 → 278
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:35 → 74
      pKID; pKID domain

    30. XM_063276087.1 → XP_063132157.1  cAMP-responsive element modulator isoform X9

    31. XM_063276097.1 → XP_063132167.1  cAMP-responsive element modulator isoform X23

    32. XM_006254054.5 → XP_006254116.1  cAMP-responsive element modulator isoform X8

      See identical proteins and their annotated locations for XP_006254116.1

      UniProtKB/TrEMBL
      A6K9H0
      Related
      ENSRNOP00000020204.7, ENSRNOT00000020204.8
      Conserved Domains (2) summary
      cd14690
      Location:248 → 302
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:59 → 98
      pKID; pKID domain

    33. XM_063276094.1 → XP_063132164.1  cAMP-responsive element modulator isoform X20

      Related
      ENSRNOP00000020012.7, ENSRNOT00000020012.8

    34. XM_063276101.1 → XP_063132171.1  cAMP-responsive element modulator isoform X28

    35. XM_063276104.1 → XP_063132174.1  cAMP-responsive element modulator isoform X31

      UniProtKB/TrEMBL
      A6K9H4

    36. XM_006254069.5 → XP_006254131.1  cAMP-responsive element modulator isoform X31

      See identical proteins and their annotated locations for XP_006254131.1

      UniProtKB/TrEMBL
      A6K9H4, Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:69 → 123
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    37. XM_006254070.5 → XP_006254132.1  cAMP-responsive element modulator isoform X34

      See identical proteins and their annotated locations for XP_006254132.1

      UniProtKB/TrEMBL
      Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:57 → 111
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    38. XM_008771691.4 → XP_008769913.1  cAMP-responsive element modulator isoform X32

      See identical proteins and their annotated locations for XP_008769913.1

      UniProtKB/TrEMBL
      Q9R1Q5
      Conserved Domains (1) summary
      cd14690
      Location:63 → 117
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013086.1: Suppressed sequence

      Description
      NM_013086.1: This RefSeq was permanently suppressed because it contains the wrong CDS, and it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03061.2 GenPept UniProtKB/Swiss-Prot:Q03061

    Gene LinkOut

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