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    Prc1 protein regulator of cytokinesis 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308761, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prc1provided by RGD
    Official Full Name
    protein regulator of cytokinesis 1provided by RGD
    Primary source
    RGD:1311754
    See related
    EnsemblRapid:ENSRNOG00000013057 AllianceGenome:RGD:1311754
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in mitotic spindle midzone assembly; positive regulation of cell population proliferation; and regulation of cytokinesis. Predicted to be located in several cellular components, including contractile ring; intercellular bridge; and midbody. Predicted to be active in cytoplasm and mitotic spindle midzone. Orthologous to human PRC1 (protein regulator of cytokinesis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 231.5), Thymus (RPKM 231.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prc1 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143659312..143681019)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (134250086..134271765)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (142087181..142108746)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene neugrin, neurite outgrowth associated Neighboring gene VPS33B, late endosome and lysosome associated Neighboring gene small nucleolar RNA SNORA48 Neighboring gene RCC1 domain containing 1 Neighboring gene unc-45 myosin chaperone A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Subramanian R, et al. Cell, 2010 Aug 6. PMID 20691902, Free PMC Article
    2. Spatiotemporal control of spindle midzone formation by PRC1 in human cells. Zhu C, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16603632, Free PMC Article
    3. Marking and measuring single microtubules by PRC1 and kinesin-4. Subramanian R, et al. Cell, 2013 Jul 18. PMID 23870126, Free PMC Article
    4. Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Kanehira M, et al. Cancer Res, 2007 Apr 1. PMID 17409436
    5. Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Neef R, et al. Nat Cell Biol, 2007 Apr. PMID 17351640

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in contractile ring ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein regulator of cytokinesis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107529.1 → NP_001100999.1  protein regulator of cytokinesis 1

      See identical proteins and their annotated locations for NP_001100999.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A6JC95, A6JC96, D3ZES9
      Related
      ENSRNOP00000017532.4, ENSRNOT00000017532.7
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 601
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143659312..143681019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229437.5 → XP_006229499.1  protein regulator of cytokinesis 1 isoform X6

      See identical proteins and their annotated locations for XP_006229499.1

      UniProtKB/TrEMBL
      A0A8I6A8F8, A0A8I6APR6, A6JC97
      Related
      ENSRNOP00000095742.1, ENSRNOT00000095280.2
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 562
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    2. XM_006229433.5 → XP_006229495.1  protein regulator of cytokinesis 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6APJ5, A6JC95
      Related
      ENSRNOP00000095649.1, ENSRNOT00000110073.2
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 615
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    3. XM_006229435.5 → XP_006229497.1  protein regulator of cytokinesis 1 isoform X4

      UniProtKB/TrEMBL
      A6JC95
      Related
      ENSRNOP00000090144.2, ENSRNOT00000101538.2
      Conserved Domains (2) summary
      pfam03999
      Location:37 → 578
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam13094
      Location:34 → 155
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit

    4. XM_063262643.1 → XP_063118713.1  protein regulator of cytokinesis 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ABV7

    5. XM_039113027.2 → XP_038968955.1  protein regulator of cytokinesis 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I6APR6
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 511
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    6. XM_039113001.2 → XP_038968929.1  protein regulator of cytokinesis 1 isoform X2

      UniProtKB/TrEMBL
      A6JC95
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 612
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    7. XM_039113007.2 → XP_038968935.1  protein regulator of cytokinesis 1 isoform X3

      UniProtKB/TrEMBL
      A6JC95
      Conserved Domains (1) summary
      pfam03999
      Location:37 → 598
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)

    8. XM_063262649.1 → XP_063118719.1  protein regulator of cytokinesis 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6APR6
    Nucleotide Protein Strain
    Heading Accession and Version

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