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    Cnnm3 cyclin and CBS domain divalent metal cation transport mediator 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnnm3provided by RGD
    Official Full Name
    cyclin and CBS domain divalent metal cation transport mediator 3provided by RGD
    Primary source
    RGD:1307926
    See related
    EnsemblRapid:ENSRNOG00000016032 AllianceGenome:RGD:1307926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Predicted to be active in plasma membrane. Orthologous to human CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 102.6), Adrenal (RPKM 83.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnnm3 in Genome Data Viewer
    Location:
    9q21
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (46251252..46266613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (38755374..38770740)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43093120..43108486)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene lectin, mannose-binding 2-like Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 4 Neighboring gene ankyrin repeat domain 23 Neighboring gene ankyrin repeat domain 39

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    metal transporter CNNM3
    Names
    cyclin M3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106901.2 → NP_001100371.2  metal transporter CNNM3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6IND7, D4ACK7
      Related
      ENSRNOP00000021591.4, ENSRNOT00000021592.8
      Conserved Domains (1) summary
      cd04590
      Location:327 → 447
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      46251252..46266613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083219.2 → XP_038939147.1  metal transporter CNNM3 isoform X4

      Conserved Domains (1) summary
      cd04590
      Location:317 → 446
      CBS_pair_CorC_HlyC_assoc; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains the majority of which are associated with the CorC_HlyC domain

    2. XM_006244756.5 → XP_006244818.1  metal transporter CNNM3 isoform X1

      UniProtKB/TrEMBL
      A6IND7
      Conserved Domains (1) summary
      cd04590
      Location:327 → 447
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

    3. XM_006244757.5 → XP_006244819.1  metal transporter CNNM3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1K3, A6IND7
      Related
      ENSRNOP00000086110.1, ENSRNOT00000115166.2
      Conserved Domains (1) summary
      cd04590
      Location:327 → 447
      CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

    4. XM_063266893.1 → XP_063122963.1  metal transporter CNNM3 isoform X3

      UniProtKB/TrEMBL
      A6IND7
    Nucleotide Protein Strain
    Heading Accession and Version

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