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    Osbpl6 oxysterol binding protein-like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Osbpl6provided by RGD
    Official Full Name
    oxysterol binding protein-like 6provided by RGD
    Primary source
    RGD:1308887
    See related
    EnsemblRapid:ENSRNOG00000010812 AllianceGenome:RGD:1308887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in regulation of cholesterol transport. Predicted to be located in early endosome membrane and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Orthologous to human OSBPL6 (oxysterol binding protein like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 105.8), Heart (RPKM 101.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl6 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (81751020..81948186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (61343776..61541170)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (63257646..63455105)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 11A Neighboring gene acidic nuclear phosphoprotein 32 family member A, pseudogene 1 Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene uncharacterized LOC134486118 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene pejvakin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Ouimet M, et al. Arterioscler Thromb Vasc Biol, 2016 May. PMID 26941018, Free PMC Article
    2. Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7. Lehto M, et al. Cell Tissue Res, 2004 Jan. PMID 14593528
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107735.2 → NP_001101205.1  oxysterol-binding protein-related protein 6 isoform d

      See identical proteins and their annotated locations for NP_001101205.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4, A6HMH5
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:570 → 911
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001431697.1 → NP_001418626.1  oxysterol-binding protein-related protein 6 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4

    3. NM_001431698.1 → NP_001418627.1  oxysterol-binding protein-related protein 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4, D4A0F3

    4. NM_001431699.1 → NP_001418628.1  oxysterol-binding protein-related protein 6 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZY24, A6HMH4

    5. NM_001431700.1 → NP_001418629.1  oxysterol-binding protein-related protein 6 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4, A6HMH5

    6. NM_001431701.1 → NP_001418630.1  oxysterol-binding protein-related protein 6 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZR1, A6HMH4

    7. NM_001431702.1 → NP_001418631.1  oxysterol-binding protein-related protein 6 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4

    8. NM_001431703.1 → NP_001418632.1  oxysterol-binding protein-related protein 6 isoform g

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AMZ3, A6HMH4

    9. NM_001431704.1 → NP_001418633.1  oxysterol-binding protein-related protein 6 isoform h

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    10. NM_001431705.1 → NP_001418634.1  oxysterol-binding protein-related protein 6 isoform i precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    11. NM_001431706.1 → NP_001418635.1  oxysterol-binding protein-related protein 6 isoform j

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    12. NM_001431707.1 → NP_001418636.1  oxysterol-binding protein-related protein 6 isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    13. NM_001431708.1 → NP_001418637.1  oxysterol-binding protein-related protein 6 isoform l

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      81751020..81948186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591693.3 → XP_017447182.1  oxysterol-binding protein-related protein 6 isoform X1

      Related
      ENSRNOP00000059467.2, ENSRNOT00000068199.4
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:603 → 944
      Oxysterol_BP; Oxysterol-binding protein

    2. XM_017591695.3 → XP_017447184.1  oxysterol-binding protein-related protein 6 isoform X2

      Related
      ENSRNOP00000112175.1, ENSRNOT00000151334.1
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:595 → 936
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_039104857.2 → XP_038960785.1  oxysterol-binding protein-related protein 6 isoform X8

      UniProtKB/TrEMBL
      A6HMH4
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:559 → 907
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_017591696.3 → XP_017447185.1  oxysterol-binding protein-related protein 6 isoform X3

      UniProtKB/TrEMBL
      A6HMH4
      Related
      ENSRNOP00000110453.1, ENSRNOT00000125272.1
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:578 → 919
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_017591698.3 → XP_017447187.1  oxysterol-binding protein-related protein 6 isoform X6

      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:570 → 911
      Oxysterol_BP; Oxysterol-binding protein

    6. XM_039104858.2 → XP_038960786.1  oxysterol-binding protein-related protein 6 isoform X12

      UniProtKB/TrEMBL
      A6HMH4
      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:534 → 882
      Oxysterol_BP; Oxysterol-binding protein

    7. XM_017591697.3 → XP_017447186.1  oxysterol-binding protein-related protein 6 isoform X5

      UniProtKB/TrEMBL
      A6HMH4
      Related
      ENSRNOP00000071146.3, ENSRNOT00000091211.3
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:572 → 913
      Oxysterol_BP; Oxysterol-binding protein

    8. XM_008761904.4 → XP_008760126.1  oxysterol-binding protein-related protein 6 isoform X7

      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:564 → 905
      Oxysterol_BP; Oxysterol-binding protein

    9. XM_008761905.4 → XP_008760127.1  oxysterol-binding protein-related protein 6 isoform X10

      UniProtKB/TrEMBL
      A6HMH4
      Related
      ENSRNOP00000095383.2, ENSRNOT00000111872.2
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:547 → 888
      Oxysterol_BP; Oxysterol-binding protein

    10. XM_008761906.4 → XP_008760128.1  oxysterol-binding protein-related protein 6 isoform X11

      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:539 → 880
      Oxysterol_BP; Oxysterol-binding protein

    11. XM_063283627.1 → XP_063139697.1  oxysterol-binding protein-related protein 6 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A0D2, A6HMH4
      Related
      ENSRNOP00000085530.1, ENSRNOT00000109671.2

    12. XM_008761907.3 → XP_008760129.1  oxysterol-binding protein-related protein 6 isoform X14

      Conserved Domains (2) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain

    13. XM_063283628.1 → XP_063139698.1  oxysterol-binding protein-related protein 6 isoform X15

    14. XM_063283630.1 → XP_063139700.1  oxysterol-binding protein-related protein 6 isoform X17

    15. XM_063283631.1 → XP_063139701.1  oxysterol-binding protein-related protein 6 isoform X18

    16. XM_063283633.1 → XP_063139703.1  oxysterol-binding protein-related protein 6 isoform X20

    17. XM_063283634.1 → XP_063139704.1  oxysterol-binding protein-related protein 6 isoform X21

    18. XM_017591694.3 → XP_017447183.1  oxysterol-binding protein-related protein 6 isoform X1

      UniProtKB/TrEMBL
      A6HMH4, D4A0F3
      Conserved Domains (3) summary
      cd13287
      Location:66 → 188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89 → 177
      PH; PH domain
      pfam01237
      Location:603 → 944
      Oxysterol_BP; Oxysterol-binding protein

    19. XM_063283629.1 → XP_063139699.1  oxysterol-binding protein-related protein 6 isoform X16

    20. XM_063283632.1 → XP_063139702.1  oxysterol-binding protein-related protein 6 isoform X19

    21. XM_063283625.1 → XP_063139695.1  oxysterol-binding protein-related protein 6 isoform X4

      Related
      ENSRNOP00000083910.1, ENSRNOT00000112703.2

    22. XM_063283626.1 → XP_063139696.1  oxysterol-binding protein-related protein 6 isoform X9

    Nucleotide Protein Strain
    Heading Accession and Version

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