Adgrg6 adhesion G protein-coupled receptor G6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Adgrg6provided by RGD
Full Name: adhesion G protein-coupled receptor G6provided by RGD
Primary source: RGD:1308551
See related: EnsemblRapid:ENSRNOG00000011411 AllianceGenome:RGD:1308551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr126
Summary: Predicted to enable G protein-coupled receptor activity and laminin binding activity. Predicted to be involved in several processes, including cAMP-mediated signaling; heart trabecula formation; and myelination in peripheral nervous system. Predicted to be located in cell surface and cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 190.4), Spleen (RPKM 83.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (10633004..10774685, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (8812889..8954239, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (8593342..8751540, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
Title: Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
This study verified that the WAR model shows down-regulation of Gpr126 in the corpus quadrigeminum.
Title: Transcriptome of the Wistar audiogenic rat (WAR) strain following audiogenic seizures.

Submit: New GeneRIF Correction

General gene information

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Markers

RH133430 (e-PCR)
- UniSTS:216713

RH47174 (e-PCR)
- UniSTS:34792

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in heart trabecula formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination in peripheral nervous system	IBA Inferred from Biological aspect of Ancestor more info
involved_in myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adhesion G-protein coupled receptor G6

Names: G-protein coupled receptor 126

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427850.1 → NP_001414779.1 adhesion G-protein coupled receptor G6 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I5Y9J5, A0A8I6ALS0

Related

ENSRNOP00000095596.2, ENSRNOT00000108246.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

10633004..10774685 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261282.1 → XP_063117352.1 adhesion G-protein coupled receptor G6 isoform X2

UniProtKB/TrEMBL

A0A8I5Y9J5
XM_218313.11 → XP_218313.7 adhesion G-protein coupled receptor G6 isoform X1

See identical proteins and their annotated locations for XP_218313.7

UniProtKB/TrEMBL

A0A0G2JST1, A0A8I5Y9J5

Related

ENSRNOP00000029263.7, ENSRNOT00000030511.8

Conserved Domains (4) summary

cd00041
Location:38 → 146

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

pfam01825
Location:799 → 844

GPS; GPCR proteolysis site, GPS, motif

cl21561
Location:861 → 1108

7tm_4; Olfactory receptor

cl22861
Location:178 → 337

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
XM_039098598.2 → XP_038954526.1 adhesion G-protein coupled receptor G6 isoform X5

Conserved Domains (3) summary

pfam01825
Location:389 → 434

GPS; GPCR proteolysis site, GPS, motif

cd14964
Location:451 → 476

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:449 → 717

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017589821.3 → XP_017445310.1 adhesion G-protein coupled receptor G6 isoform X3

UniProtKB/TrEMBL

A0A8I5Y9J5

Related

ENSRNOP00000094336.2, ENSRNOT00000109442.2
XM_017589822.3 → XP_017445311.1 adhesion G-protein coupled receptor G6 isoform X4

UniProtKB/TrEMBL

A0A8I5Y9J5, A0A8I6ALD7

Related

ENSRNOP00000077463.2, ENSRNOT00000099051.2