Ttll11 tubulin tyrosine ligase like11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttll11provided by RGD
Official Full Name: tubulin tyrosine ligase like11provided by RGD
Primary source: RGD:1588742
See related: EnsemblRapid:ENSRNOG00000019339 AllianceGenome:RGD:1588742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within microtubule severing and protein polyglutamylation. Predicted to be active in ciliary basal body. Orthologous to human TTLL11 (tubulin tyrosine ligase like 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 30.7), Testes (RPKM 27.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (39507714..39732893, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (19109891..19335077, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (15084244..15312312, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D3Got14 (e-PCR)
- UniSTS:112401

BF390128 (e-PCR)
- UniSTS:249391

RH135432 (e-PCR)
- UniSTS:218709

BE108128 (e-PCR)
- UniSTS:247658

D3Got8 (e-PCR)
- UniSTS:113056

D3MGH19 (e-PCR)
- UniSTS:121780

BF390698 (e-PCR)
- UniSTS:249525

AU049664 (e-PCR)
- UniSTS:146110

RH140322 (e-PCR)
- UniSTS:222399

D3Got15 (e-PCR)
- UniSTS:115151

RH140350 (e-PCR)
- UniSTS:222426

D3Mit22 (e-PCR), detects polymorphism
- UniSTS:239592

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule severing	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein polyglutamylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tubulin polyglutamylase TTLL11

Names: tubulin tyrosine ligase-like family, member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431779.1 → NP_001418708.1 tubulin polyglutamylase TTLL11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8J8YGC3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

39507714..39732893 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284853.1 → XP_063140923.1 tubulin polyglutamylase TTLL11 isoform X4
XM_017592137.3 → XP_017447626.3 tubulin polyglutamylase TTLL11 isoform X3
XM_001071863.8 → XP_001071863.5 tubulin polyglutamylase TTLL11 isoform X2

Related

ENSRNOP00000037724.6, ENSRNOT00000032204.7
XM_017592136.3 → XP_017447625.3 tubulin polyglutamylase TTLL11 isoform X1

UniProtKB/TrEMBL

A0A8I6AD63

Related

ENSRNOP00000090192.1, ENSRNOT00000118896.2
XM_063284855.1 → XP_063140925.1 tubulin polyglutamylase TTLL11 isoform X7

UniProtKB/TrEMBL

A6JUG2, B5DFG3, F1LPS9
XM_039106239.2 → XP_038962167.1 tubulin polyglutamylase TTLL11 isoform X6

UniProtKB/TrEMBL

A6JUG2

Conserved Domains (1) summary

cl17255
Location:1 → 261

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
XM_039106238.2 → XP_038962166.2 tubulin polyglutamylase TTLL11 isoform X5