Cxcr5 C-X-C motif chemokine receptor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcr5provided by RGD
Official Full Name: C-X-C motif chemokine receptor 5provided by RGD
Primary source: RGD:62010
See related: EnsemblRapid:ENSRNOG00000012430 AllianceGenome:RGD:62010
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NLR; Blr1
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; positive regulation of cytokinesis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within leukocyte chemotaxis and lymph node development. Predicted to be active in external side of plasma membrane. Orthologous to human CXCR5 (C-X-C motif chemokine receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 126.3), Thymus (RPKM 30.4) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53738878..53756813, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44842098..44858425, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48835688..48852032, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats.
Title: Mechanism of IRF5-regulated CXCL13/CXCR5 Signaling Axis in CCI-induced Neuropathic Pain in Rats.
CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3.
Title: CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-X-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell activation	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in lymph node development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lymph node development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-X-C chemokine receptor type 5

Names: CXC-R5; CXCR-5; burkitt lymphoma receptor 1 homolog; chemochine (C-X-C motif) receptor 5; chemokine (C-X-C motif) receptor 5; neurolymphatic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053303.1 → NP_445755.1 C-X-C chemokine receptor type 5

See identical proteins and their annotated locations for NP_445755.1

Status: PROVISIONAL

Source sequence(s)

X71463

UniProtKB/Swiss-Prot

P34997

Conserved Domains (1) summary

pfam00001
Location:70 → 324

7tm_1; 7 transmembrane receptor (rhodopsin family)