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    Ighe immunoglobulin heavy constant epsilon [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299351, updated on 4-Jan-2025

    Summary

    Official Symbol
    Igheprovided by RGD
    Official Full Name
    immunoglobulin heavy constant epsilonprovided by RGD
    Primary source
    RGD:2880
    See related
    AllianceGenome:RGD:2880
    Gene type
    other
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IGH2
    Summary
    Predicted to enable MHC class II protein complex binding activity; immunoglobulin receptor binding activity; and peptide antigen binding activity. Predicted to be involved in several processes, including B cell activation; B cell mediated immunity; and leukocyte degranulation. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of IgE B cell receptor complex and MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Orthologous to human IGHE (immunoglobulin heavy constant epsilon). [provided by Alliance of Genome Resources, Jan 2025]
    Annotation information
    not in current annotation release
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    Genomic context

    See Ighe in Genome Data Viewer
    Location:
    6q32
    Annotation release Status Assembly Chr Location
    106 latest, but not current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (138066728..138068606, complement)
    106 latest, but not current Rn_Celera (GCF_000002265.2) 6 AC_000074.1 (129872683..129874561, complement)

    General gene information

    Other Names

    • Ig epsilon chain C region
    • immunoglobulin heavy chain (epsilon polypeptide)

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class II protein complex binding  
    enables immunoglobulin receptor binding  
    enables peptide antigen binding  
    Process Evidence Code Pubs
    involved_in B cell antigen processing and presentation  
    involved_in B cell differentiation  
    involved_in B cell proliferation  
    involved_in B cell receptor signaling pathway  
    involved_in Fc receptor-mediated immune complex endocytosis  
    involved_in adaptive immune memory response  
    involved_in antibody-dependent cellular cytotoxicity  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
    involved_in eosinophil degranulation  
    involved_in macrophage activation  
    involved_in macrophage differentiation  
    involved_in mast cell degranulation  
    involved_in peptide antigen assembly with MHC class II protein complex  
    involved_in positive regulation of T cell activation  
    involved_in positive regulation of immune response  
    involved_in primary adaptive immune response  
    involved_in type 2 immune response  
    involved_in type I hypersensitivity  
    Component Evidence Code Pubs
    part_of IgE B cell receptor complex  
    part_of MHC class II protein complex  
    is_active_in cytoplasm  
    located_in extracellular region  
    located_in extracellular space  
    is_active_in late endosome membrane  
    is_active_in lysosomal membrane  
    located_in plasma membrane  
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