U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Lgals3 galectin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83781, updated on 4-Jan-2025

    Summary

    Official Symbol
    Lgals3provided by RGD
    Official Full Name
    galectin 3provided by RGD
    Primary source
    RGD:69356
    See related
    EnsemblRapid:ENSRNOG00000010645 AllianceGenome:RGD:69356
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    L-34; CBP30; gal-3; AGE-R3
    Summary
    Enables several functions, including Fc-gamma receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of serotonin secretion; and response to quercetin. Located in cell surface and extracellular space. Biomarker of several diseases, including acute kidney failure; attention deficit hyperactivity disorder; brain ischemia; colon cancer; and congestive heart failure. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 642.0), Spleen (RPKM 448.5) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lgals3 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (23099795..23111731)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20620083..20632019)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (24153602..24165537)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097123 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 8 Neighboring gene DLG associated protein 5 Neighboring gene uncharacterized LOC120096955

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Clone Names

    • MGC105387

    Gene Ontology Provided by RGD

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables Fc-gamma receptor I complex binding PubMed 
    enables IgE binding  
    enables IgE binding PubMed 
    enables IgE binding  
    enables IgE binding  
    enables advanced glycation end-product receptor activity PubMed 
    enables carbohydrate binding  
    enables carbohydrate binding  
    enables chemoattractant activity  
    enables chemoattractant activity  
    enables disaccharide binding  
    enables disaccharide binding PubMed 
    enables laminin binding  
    enables laminin binding  
    enables laminin binding  
    enables molecular condensate scaffold activity  
    enables molecular condensate scaffold activity  
    enables monosaccharide binding PubMed 
    enables oligosaccharide binding  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein phosphatase inhibitor activity  
    enables protein phosphatase inhibitor activity  
    enables receptor ligand inhibitor activity  
    enables receptor ligand inhibitor activity  
    enables signaling receptor inhibitor activity  
    enables signaling receptor inhibitor activity  
    Items 1 - 25 of 27
    Items 1 - 25 of 59
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in cell differentiation  
    involved_in eosinophil chemotaxis  
    involved_in eosinophil chemotaxis  
    involved_in eosinophil chemotaxis  
    involved_in epithelial cell differentiation  
    involved_in epithelial cell differentiation  
    acts_upstream_of_or_within extracellular matrix organization  
    involved_in innate immune response  
    involved_in mRNA processing  
    involved_in macrophage chemotaxis  
    involved_in macrophage chemotaxis  
    involved_in macrophage chemotaxis  
    NOT involved_in maintenance of protein location  
    involved_in monocyte chemotaxis  
    involved_in monocyte chemotaxis  
    involved_in monocyte chemotaxis  
    involved_in mononuclear cell migration  
    involved_in negative regulation of NK T cell activation  
    involved_in negative regulation of NK T cell activation  
    involved_in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  
    involved_in negative regulation of T cell receptor signaling pathway  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of cell proliferation in bone marrow PubMed 
    involved_in negative regulation of endocytosis  
    involved_in negative regulation of endocytosis  
    involved_in negative regulation of endocytosis  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of immunological synapse formation  
    involved_in neutrophil chemotaxis  
    involved_in neutrophil chemotaxis  
    involved_in neutrophil chemotaxis  
    involved_in positive chemotaxis  
    involved_in positive chemotaxis  
    involved_in positive chemotaxis  
    involved_in positive regulation of angiogenesis PubMed 
    involved_in positive regulation of calcium ion import  
    involved_in positive regulation of calcium ion import  
    involved_in positive regulation of calcium ion import  
    involved_in positive regulation of cell population proliferation PubMed 
    NOT involved_in positive regulation of dendritic cell differentiation  
    involved_in positive regulation of mononuclear cell migration  
    involved_in positive regulation of mononuclear cell migration  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of serotonin secretion PubMed 
    involved_in regulation of T cell apoptotic process  
    involved_in regulation of T cell apoptotic process  
    involved_in regulation of T cell proliferation  
    involved_in regulation of T cell proliferation  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in response to quercetin PubMed 
    acts_upstream_of_or_within skeletal system development  
    Items 1 - 25 of 59
    Items 1 - 20 of 27
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in cell surface  
    is_active_in cornified envelope  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in external side of plasma membrane  
    located_in extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular space  
    located_in glial cell projection  
    is_active_in immunological synapse  
    located_in immunological synapse  
    located_in immunological synapse  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    part_of spliceosomal complex  
    Items 1 - 20 of 27

    General protein information

    Preferred Names
    galectin-3
    Names
    35 kDa lectin
    CBP 35
    IgE binding protein
    carbohydrate-binding protein 35
    epsilon BP
    galactose-specific lectin 3
    igE-binding protein
    laminin-binding protein
    lectin L-29
    lectin galactoside-binding soluble 3 protein
    lectin, galactose binding, soluble 3
    lectin, galactoside-binding, soluble, 3
    mac-2 antigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031832.1NP_114020.1  galectin-3

      See identical proteins and their annotated locations for NP_114020.1

      Status: PROVISIONAL

      Source sequence(s)
      J02962
      UniProtKB/TrEMBL
      V5QR27
      Related
      ENSRNOP00000070203.2, ENSRNOT00000082675.3
      Conserved Domains (2) summary
      cd00070
      Location:129256
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
      pfam02084
      Location:18116
      Bindin; Bindin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      23099795..23111731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093700.1XP_038949628.1  galectin-3 isoform X1

      UniProtKB/Swiss-Prot
      P08699
      UniProtKB/TrEMBL
      A6KE45, V5QQP9, V5QR27, V5QRT4
      Related
      ENSRNOP00000014216.3, ENSRNOT00000014216.7
      Conserved Domains (2) summary
      PRK07764
      Location:9137
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00070
      Location:129256
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
    External link. Please review our privacy policy.