U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Elmo1 engulfment and cell motility 1 [ Mus musculus (house mouse) ]

    Gene ID: 140580, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    Elmo1provided by MGI
    Official Full Name
    engulfment and cell motility 1provided by MGI
    Primary source
    MGI:MGI:2153044
    See related
    Ensembl:ENSMUSG00000041112 AllianceGenome:MGI:2153044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CED-12; 6330578D22Rik; C230095H21Rik
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Acts upstream of or within actin filament-based process and phagocytosis. Part of guanyl-nucleotide exchange factor complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; retina; and vibrissa. Orthologous to human ELMO1 (engulfment and cell motility 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 18.2), thymus adult (RPKM 13.4) and 27 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Elmo1 in Genome Data Viewer
    Location:
    13 A2; 13 7.21 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (20274677..20792523)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (20090507..20608353)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 141 Neighboring gene STARR-seq mESC enhancer starr_33803 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33804 Neighboring gene STARR-seq mESC enhancer starr_33805 Neighboring gene predicted gene 5446 Neighboring gene STARR-seq mESC enhancer starr_33809 Neighboring gene STARR-positive B cell enhancer ABC_E11780 Neighboring gene STARR-seq mESC enhancer starr_33810 Neighboring gene STARR-positive B cell enhancer ABC_E7207 Neighboring gene STARR-positive B cell enhancer ABC_E4052 Neighboring gene STARR-seq mESC enhancer starr_33811 Neighboring gene STARR-positive B cell enhancer ABC_E5371 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:20299067-20299268 Neighboring gene STARR-seq mESC enhancer starr_33815 Neighboring gene STARR-seq mESC enhancer starr_33817 Neighboring gene STARR-seq mESC enhancer starr_33818 Neighboring gene predicted gene, 32036 Neighboring gene STARR-seq mESC enhancer starr_33821 Neighboring gene STARR-seq mESC enhancer starr_33822 Neighboring gene predicted gene 7614 Neighboring gene STARR-seq mESC enhancer starr_33823 Neighboring gene acyloxyacyl hydrolase Neighboring gene STARR-seq mESC enhancer starr_33824 Neighboring gene STARR-seq mESC enhancer starr_33826 Neighboring gene predicted gene, 32242

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Altering the expression in mice of genes by modifying their 3' regions. Kakoki M, et al. Dev Cell, 2004 Apr. PMID 15068798
    2. ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection. Sarkar A, et al. J Infect Dis, 2017 Dec 19. PMID 29029244, Free PMC Article
    3. The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses. Sayed IM, et al. Gut Microbes, 2021 Jan-Dec. PMID 34719317, Free PMC Article
    4. ELMO1 signaling is a promoter of osteoclast function and bone loss. Arandjelovic S, et al. Nat Commun, 2021 Aug 17. PMID 34404802, Free PMC Article
    5. ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts. Liang X, et al. Front Cell Dev Biol, 2021. PMID 34381782, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis.
      Title: ELMO1 Deficiency Reduces Neutrophil Chemotaxis in Murine Peritonitis.
    2. The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses.
      Title: The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses.
    3. TNF-alpha/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells.
      Title: TNF-α/ENO1 signaling facilitates testicular phagocytosis by directly activating Elmo1 gene expression in mouse Sertoli cells.
    4. The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses.
      Title: The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses.
    5. ELMO1 signaling is a promoter of osteoclast function and bone loss.
      Title: ELMO1 signaling is a promoter of osteoclast function and bone loss.
    6. Host engulfment pathway controls inflammation in inflammatory bowel disease.
      Title: Host engulfment pathway controls inflammation in inflammatory bowel disease.
    7. Platelet aggregation, granule secretion, integrin alphaIIbbeta3 activation, and thromboxane generation were enhanced in ELMO1(-/-) platelets in response to glycoprotein VI (GPVI) agonists but unaltered when a protease-activated receptor 4 agonist was used. These results indicate that ELMO1 plays an important role in hemostasis and thrombosis in vivo.
      Title: ELMO1 deficiency enhances platelet function.
    8. ELMO1 protects against DSS-induced colonic injury in mice through its effect on epithelial migration via Rac1 activation.
      Title: Engulfment and Cell Motility Protein 1 Protects Against DSS-induced Colonic Injury in Mice via Rac1 Activation.
    9. Loss of the engulfment signaling protein Elmo1 alleviated disease severity in mouse models of arthritis through Elmo1's regulation of neutrophil recruitment to inflamed joints.
      Title: A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.
    10. ELMO1 is present in the phagosome and enhances bacterial clearance by differential regulation of lysosomal acidification and enzymatic activity.
      Title: ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (4) 
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA0281

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Rac protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament-based process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of guanyl-nucleotide exchange factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    engulfment and cell motility protein 1
    Names
    engulfment and cell motility 1, ced-12 homolog

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080288.2 → NP_525027.1  engulfment and cell motility protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
      Source sequence(s)
      AC124183, AC124751, AC126555, AC132085, AC153143, AC165346
      Consensus CDS
      CCDS26265.1
      UniProtKB/Swiss-Prot
      Q8BPU7, Q8BSY9, Q8K2C5, Q91ZU3
      UniProtKB/TrEMBL
      Q571D6
      Related
      ENSMUSP00000072334.5, ENSMUST00000072519.7
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    2. NM_198093.3 → NP_932761.1  engulfment and cell motility protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 3.
      Source sequence(s)
      AK049051, BB647467, BC024727, BE943952
      UniProtKB/Swiss-Prot
      Q8BPU7
      Related
      ENSMUSP00000160033.1, ENSMUST00000249938.1
      Conserved Domains (1) summary
      cd13359
      Location:66 → 195
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      20274677..20792523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516544.4 → XP_006516607.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      Q571D6
      Conserved Domains (3) summary
      cd13359
      Location:561 → 690
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:318 → 496
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 294
      DUF3361; Domain of unknown function (DUF3361)

    2. XM_006516547.3 → XP_006516610.1  engulfment and cell motility protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8BPU7, Q8BSY9, Q8K2C5, Q91ZU3
      UniProtKB/TrEMBL
      Q571D6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    3. XM_006516546.3 → XP_006516609.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      Q571D6
      Conserved Domains (3) summary
      cd13359
      Location:561 → 690
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:318 → 496
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 294
      DUF3361; Domain of unknown function (DUF3361)

    4. XM_006516545.5 → XP_006516608.1  engulfment and cell motility protein 1 isoform X1

      UniProtKB/TrEMBL
      Q571D6
      Conserved Domains (3) summary
      cd13359
      Location:561 → 690
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:318 → 496
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 294
      DUF3361; Domain of unknown function (DUF3361)

    5. XM_030247141.2 → XP_030103001.1  engulfment and cell motility protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8BPU7, Q8BSY9, Q8K2C5, Q91ZU3
      UniProtKB/TrEMBL
      Q571D6
      Conserved Domains (3) summary
      cd13359
      Location:546 → 675
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:303 → 481
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:116 → 279
      DUF3361; Domain of unknown function (DUF3361)

    6. XM_030247142.1 → XP_030103002.1  engulfment and cell motility protein 1 isoform X3

      UniProtKB/TrEMBL
      Q571D6
      Conserved Domains (3) summary
      cd13359
      Location:465 → 594
      PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain
      pfam04727
      Location:222 → 400
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:20 → 198
      DUF3361; Domain of unknown function (DUF3361)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BPU7.2 GenPept UniProtKB/Swiss-Prot:Q8BPU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous