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    Crk v-crk avian sarcoma virus CT10 oncogene homolog [ Mus musculus (house mouse) ]

    Gene ID: 12928, updated on 4-Jan-2025

    Summary

    Official Symbol
    Crkprovided by MGI
    Official Full Name
    v-crk avian sarcoma virus CT10 oncogene homologprovided by MGI
    Primary source
    MGI:MGI:88508
    See related
    Ensembl:ENSMUSG00000017776 AllianceGenome:MGI:88508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p38; Crk3; Crko; Crk-I; c-Crk; Crk-II; CrkIII; Crk-III
    Summary
    This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.5), bladder adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Crk in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75570020..75599254)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75679194..75708428)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3974 Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene STARR-positive B cell enhancer ABC_E3975 Neighboring gene myosin IC Neighboring gene STARR-positive B cell enhancer ABC_E7018 Neighboring gene STARR-positive B cell enhancer ABC_E3001 Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene double C2, beta Neighboring gene predicted gene 12339

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables SH2 domain binding  
    enables SH2 domain binding  
    enables SH3 domain binding  
    enables SH3 domain binding  
    enables cytoskeletal protein binding  
    enables cytoskeletal protein binding  
    enables enzyme binding  
    enables ephrin receptor binding PubMed 
    enables ephrin receptor binding  
    enables insulin-like growth factor receptor binding  
    enables insulin-like growth factor receptor binding  
    enables kinase binding  
    enables phosphotyrosine residue binding  
    enables phosphotyrosine residue binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein phosphorylated amino acid binding PubMed 
    enables protein phosphorylated amino acid binding  
    enables protein tyrosine kinase binding  
    enables protein tyrosine kinase binding  
    enables protein-macromolecule adaptor activity  
    enables receptor tyrosine kinase binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables signaling adaptor activity  
    enables signaling adaptor activity PubMed 
    enables signaling adaptor activity  
    enables signaling receptor complex adaptor activity PubMed 
    enables ubiquitin protein ligase binding PubMed 
    Items 1 - 25 of 29
    Items 1 - 25 of 75
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    acts_upstream_of_or_within activation of GTPase activity PubMed 
    acts_upstream_of_or_within cell chemotaxis PubMed 
    involved_in cell migration  
    involved_in cell population proliferation PubMed 
    involved_in cellular response to endothelin  
    involved_in cellular response to endothelin  
    involved_in cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to insulin-like growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus  
    involved_in cellular response to nitric oxide  
    involved_in cellular response to nitric oxide  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in cellular response to transforming growth factor beta stimulus  
    acts_upstream_of_or_within cerebellar neuron development PubMed 
    acts_upstream_of_or_within cerebral cortex development PubMed 
    acts_upstream_of_or_within dendrite development PubMed 
    involved_in enzyme-linked receptor protein signaling pathway  
    involved_in enzyme-linked receptor protein signaling pathway PubMed 
    involved_in enzyme-linked receptor protein signaling pathway PubMed 
    involved_in enzyme-linked receptor protein signaling pathway PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    acts_upstream_of_or_within establishment of cell polarity PubMed 
    acts_upstream_of_or_within helper T cell diapedesis PubMed 
    acts_upstream_of_or_within hippocampus development PubMed 
    acts_upstream_of_or_within lipid metabolic process PubMed 
    involved_in negative regulation of cell motility  
    involved_in negative regulation of cell motility  
    involved_in negative regulation of natural killer cell mediated cytotoxicity  
    involved_in negative regulation of natural killer cell mediated cytotoxicity  
    involved_in negative regulation of wound healing  
    involved_in negative regulation of wound healing  
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of Rac protein signal transduction PubMed 
    involved_in positive regulation of cell growth  
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering PubMed 
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering PubMed 
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering PubMed 
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of smooth muscle cell migration  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in postsynaptic specialization assembly PubMed 
    involved_in postsynaptic specialization assembly PubMed 
    involved_in protein localization to membrane  
    involved_in protein localization to membrane  
    acts_upstream_of_or_within reelin-mediated signaling pathway PubMed 
    involved_in regulation of GTPase activity  
    involved_in regulation of GTPase activity  
    involved_in regulation of Rac protein signal transduction  
    acts_upstream_of_or_within regulation of T cell migration PubMed 
    acts_upstream_of_or_within regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    acts_upstream_of_or_within regulation of cell adhesion mediated by integrin PubMed 
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    acts_upstream_of_or_within regulation of dendrite development PubMed 
    involved_in regulation of intracellular signal transduction  
    acts_upstream_of_or_within regulation of leukocyte migration PubMed 
    involved_in regulation of signal transduction  
    involved_in response to cholecystokinin  
    involved_in response to cholecystokinin  
    involved_in response to hepatocyte growth factor  
    involved_in response to hepatocyte growth factor  
    involved_in response to hydrogen peroxide  
    involved_in response to hydrogen peroxide  
    involved_in response to peptide  
    involved_in response to peptide  
    involved_in response to yeast  
    Items 1 - 25 of 75
    Component Evidence Code Pubs
    located_in actin cytoskeleton PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in membrane PubMed 
    is_active_in neuromuscular junction PubMed 
    is_active_in neuromuscular junction PubMed 
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    adapter molecule crk
    Names
    CT-10 related kinase 3
    avian sarcoma virus CT10 (v-crk) oncogene homolog
    proto-oncogene c-crk
    v-crk sarcoma virus CT10 oncogene-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277219.1NP_001264148.1  adapter molecule crk isoform 1

      See identical proteins and their annotated locations for NP_001264148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform 1 (also known as CrkI). Isoform 1 (CrkI) contains the SH2 domain and the N-terminal SH3 domain, both of which are proposed to be crucial for development.
      Source sequence(s)
      AK139089, AL591440
      Consensus CDS
      CCDS70241.1
      UniProtKB/TrEMBL
      Q8JZR2
      Related
      ENSMUSP00000104063.2, ENSMUST00000108425.8
      Conserved Domains (2) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    2. NM_001277221.1NP_001264150.1  adapter molecule crk isoform 3

      See identical proteins and their annotated locations for NP_001264150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate, in-frame exon in the coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1 (CrkI). Isoform 3 does not have a complete SH2 domain and lacks an SH3 domain, both of which are found in isoform 1.
      Source sequence(s)
      AL591440
      Consensus CDS
      CCDS70242.1
      UniProtKB/TrEMBL
      Q3TQV3
      Related
      ENSMUSP00000104064.2, ENSMUST00000108426.8
      Conserved Domains (1) summary
      cl15255
      Location:563
      SH2; Src homology 2 (SH2) domain
    3. NM_133656.5NP_598417.2  adapter molecule crk isoform 2

      See identical proteins and their annotated locations for NP_598417.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate segment, compared to variant 1, resulting in a longer protein (isoform 2, also known as CrkII) that has a distinct C-terminus and an additional SH3 domain, compared to isoform 1 (CrkI). Isoform 2 (CrkII) is proposed to have a negative regulatory role.
      Source sequence(s)
      AK028488, AL591440
      Consensus CDS
      CCDS25055.1
      UniProtKB/Swiss-Prot
      Q64010
      UniProtKB/TrEMBL
      Q5ND51, Q91VM1
      Related
      ENSMUSP00000017920.8, ENSMUST00000017920.14
      Conserved Domains (3) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:237293
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75570020..75599254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532125.3XP_006532188.1  adapter molecule crk isoform X2

      See identical proteins and their annotated locations for XP_006532188.1

      UniProtKB/TrEMBL
      Q3TTI0, Q5ND50
      Related
      ENSMUSP00000090803.4, ENSMUST00000093115.4
      Conserved Domains (2) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
    2. XM_006532124.4XP_006532187.1  adapter molecule crk isoform X1

      See identical proteins and their annotated locations for XP_006532187.1

      UniProtKB/TrEMBL
      Q920I1
      Related
      ENSMUSP00000116527.2, ENSMUST00000147718.2
      Conserved Domains (3) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cl17036
      Location:237259
      SH3; Src Homology 3 domain superfamily
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