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    CCDC26 CCDC26 long non-coding RNA [ Homo sapiens (human) ]

    Gene ID: 137196, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CCDC26provided by HGNC
    Official Full Name
    CCDC26 long non-coding RNAprovided by HGNC
    Primary source
    HGNC:HGNC:28416
    See related
    Ensembl:ENSG00000229140 MIM:613040; AllianceGenome:HGNC:28416
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAM; GLM7
    Summary
    Implicated in brain cancer and high grade glioma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See CCDC26 in Genome Data Viewer
    Location:
    8q24.21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (129351694..129680239, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (130477623..130806200, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (130363940..130692485, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27963 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:130314706-130315206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:130315207-130315707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27964 Neighboring gene RN7SK pseudogene 206 Neighboring gene MPRA-validated peak7173 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:130343219-130344418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27966 Neighboring gene Sharpr-MPRA regulatory region 4396 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130526802-130527734 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130527735-130528668 Neighboring gene microRNA 3686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27969 Neighboring gene CRISPRi-validated CCDC26 and MYC e5 enhancer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:130598970-130600169 Neighboring gene MPRA-validated peak7175 silencer Neighboring gene VISTA enhancer hs1709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19540 Neighboring gene CRISPRi-validated CCDC26, MYC and PVT1 e6 enhancer Neighboring gene CRISPRi-validated CCDC26, MYC and PVT1 e7 enhancer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:130719165-130720364 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:130722337-130723536 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:130725004-130725177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27970 Neighboring gene mitochondrial translational release factor 1 like pseudogene 2 Neighboring gene gasdermin C Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130844878-130845690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:130845691-130846502 Neighboring gene ribosomal protein L15 pseudogene 12 Neighboring gene CYFIP related Rac1 interactor B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Genes encoded within 8q24 on the amplicon of a large extrachromosomal element are selectively repressed during the terminal differentiation of HL-60 cells. Hirano T, et al. Mutat Res, 2008 Apr 2. PMID 18243251
    2. Genetic Polymorphisms of CCDC26 rs891835, rs6470745, and rs55705857 in Glioma Risk: A Systematic Review and Meta-analysis. González-Castro TB, et al. Biochem Genet, 2019 Aug. PMID 30778791
    3. Differential distribution of CCDC26 glioma-risk alleles in myeloid malignancies with mutant IDH1 compared with their IDH2R140-mutated or IDH-unmutated counterparts. Lasho TL, et al. Leukemia, 2012 Jun. PMID 22116548
    4. CCDC26 rs4295627 polymorphisms associated with an increased risk of glioma: A meta-analysis. Zeng J, et al. Adv Clin Exp Med, 2017 Nov. PMID 29264887
    5. Long noncoding RNA CCDC26 as a potential predictor biomarker contributes to tumorigenesis in pancreatic cancer. Peng W, et al. Biomed Pharmacother, 2016 Oct. PMID 27470572

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins.
      Title: Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins.
    2. Findings suggest a possible participation of rs891835, rs6470745, and rs55705857 as risk factors to develop glioma. Review.
      Title: Genetic Polymorphisms of CCDC26 rs891835, rs6470745, and rs55705857 in Glioma Risk: A Systematic Review and Meta-analysis.
    3. No differences were found between the combined AML patient populations and the healthy controls with respect to the expression levels of PVT1, CCDC26, and CCAT1. Compared with the healthy controls, -M2 and AML-M4/M5 patients had higher CCDC26 expression (p < 0.001 and p = 0.02, respectively).
      Title: Expression Analysis of PVT1, CCDC26, and CCAT1 Long Noncoding RNAs in Acute Myeloid Leukemia Patients.
    4. Research indicated a CCDC26/miR-203 pathway in regulating the growth and metastasis of gliomas.
      Title: Silencing of lncRNA CCDC26 Restrains the Growth and Migration of Glioma Cells In Vitro and In Vivo via Targeting miR-203.
    5. show that the G allele of the CCDC26 rs4295627 polymorphism significantly increases the risk of glioma
      Title: CCDC26 rs4295627 polymorphisms associated with an increased risk of glioma: A meta-analysis.
    6. CCDC26 may be identified as a novel oncogene in pancreatic cancer.
      Title: Long noncoding RNA CCDC26 as a potential predictor biomarker contributes to tumorigenesis in pancreatic cancer.
    7. Meta-analysis suggests that the rs4295627 SNP is associated with an increased risk of glioma.
      Title: CCDC26 rs4295627 polymorphism (8q24.21) and glioma risk: a meta-analysis.
    8. CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression.
      Title: Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression.
    9. CCDC26 controls growth of myeloid leukemia cells through regulation of KIT expression. CCDC26 knockdown in K562 cells results in lowered growth in medium with high concentration of serum and inhibition of apoptosis in serum depleted medium. Activation of KIT expression in KD cells was observed. A tyrosine kinase inhibitor specific to KIT eliminated these effects.
      Title: Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression.
    10. Single nucleotide polymorphisms in CDKN2BAS are associated with increased susceptibility to pediatric brain tumors.
      Title: CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Glioma susceptibility 7
    MedGen: C2751638 OMIM: 613032 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Chromosome 7p11.2 (EGFR) variation influences glioma risk.
    EBI GWAS Catalog
    Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
    EBI GWAS Catalog
    Genome-wide association study identifies five susceptibility loci for glioma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • CASC8/CCDC26 fusion
    • PVT1/CCDC26 fusion
    • Putative coiled-coil domain-containing protein 26
    • coiled-coil domain containing 26
    • retinoic acid modulator

    Clone Names

    • MGC27434

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_130917.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC013300, BC070152
      Related
      ENST00000446592.7

    2. NR_130918.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two exons and contains an alternate 5' terminal exon, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC013300, BC026098, BC070152, BG532915
      Related
      ENST00000523151.6

    3. NR_130919.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons and contains two alternate 5' exons, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC013300, BC070152, BG393734, BG532915
      Related
      ENST00000676273.1

    4. NR_130920.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two exons and contains two alternate 5' exons, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AC013300, BC070152, BG532915, BU186641
      Related
      ENST00000661447.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      129351694..129680239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      130477623..130806200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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