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    H4C7 H4 clustered histone 7 [ Homo sapiens (human) ]

    Gene ID: 8369, updated on 9-Dec-2024

    Summary

    Official Symbol
    H4C7provided by HGNC
    Official Full Name
    H4 clustered histone 7provided by HGNC
    Primary source
    HGNC:HGNC:4792
    See related
    Ensembl:ENSG00000275663 MIM:602832; AllianceGenome:HGNC:4792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H4/l; H4FL; HIST1H4G
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
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    Genomic context

    See H4C7 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26246611..26246996, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26115083..26115468, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26246839..26247224, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26234741-26235728 Neighboring gene H1.3 linker histone, cluster member Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24219 Neighboring gene H4 clustered histone 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24222 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:26251592-26252322 Neighboring gene H3 clustered histone 7 Neighboring gene H2B clustered histone 9

    Genomic regions, transcripts, and products

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    histone H4-like protein type G
    Names
    H4 histone family, member L
    histone 1, H4g
    histone cluster 1 H4 family member g
    histone cluster 1, H4g

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003547.3NP_003538.1  histone H4-like protein type G

      See identical proteins and their annotated locations for NP_003538.1

      Status: REVIEWED

      Source sequence(s)
      AL031777
      Consensus CDS
      CCDS4599.1
      UniProtKB/Swiss-Prot
      Q99525
      Related
      ENSP00000477870.2, ENST00000611444.2
      Conserved Domains (1) summary
      PTZ00015
      Location:1998
      PTZ00015; histone H4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26246611..26246996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      26115083..26115468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)