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    OR6N1 olfactory receptor family 6 subfamily N member 1 [ Homo sapiens (human) ]

    Gene ID: 128372, updated on 10-Dec-2024

    Summary

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    Official Symbol
    OR6N1provided by HGNC
    Official Full Name
    olfactory receptor family 6 subfamily N member 1provided by HGNC
    Primary source
    HGNC:HGNC:15034
    See related
    Ensembl:ENSG00000197403 AllianceGenome:HGNC:15034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR1-22
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See OR6N1 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (158764236..158840396, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (157901319..157977489, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158734026..158741985, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily K member 5 pseudogene Neighboring gene olfactory receptor family 6 subfamily K member 6 Neighboring gene olfactory receptor family 6 subfamily N member 2 Neighboring gene olfactory receptor family 2 subfamily AQ member 1 pseudogene Neighboring gene olfactory receptor family 10 subfamily AA member 1 pseudogene Neighboring gene myeloid cell nuclear differentiation antigen Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:158856217-158856716 Neighboring gene pyrin and HIN domain family member 5, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:158879152-158879652 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:158908087-158909286 Neighboring gene pyrin and HIN domain family member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:158922455-158923423 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:158928812-158928990

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 6N1
    Names
    olfactory receptor OR1-22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005185.2 → NP_001005185.1  olfactory receptor 6N1

      See identical proteins and their annotated locations for NP_001005185.1

      Status: VALIDATED

      Source sequence(s)
      AL513205
      Consensus CDS
      CCDS30905.1
      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3
      Related
      ENSP00000493254.1, ENST00000641846.1
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40 → 305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      158764236..158840396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000325.2 → XP_016855814.1  olfactory receptor 6N1 isoform X1

      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40 → 305
      7tm_4; Olfactory receptor

    2. XM_017000327.2 → XP_016855816.1  olfactory receptor 6N1 isoform X1

      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40 → 305
      7tm_4; Olfactory receptor

    3. XM_017000326.2 → XP_016855815.1  olfactory receptor 6N1 isoform X1

      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3
      Conserved Domains (2) summary
      pfam00001
      Location:41 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40 → 305
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      157901319..157977489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334458.1 → XP_054190433.1  olfactory receptor 6N1 isoform X1

      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3

    2. XM_054334460.1 → XP_054190435.1  olfactory receptor 6N1 isoform X1

      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3

    3. XM_054334459.1 → XP_054190434.1  olfactory receptor 6N1 isoform X1

      UniProtKB/Swiss-Prot
      B2RUT4, Q5VUU8, Q8NGY5, Q96R35
      UniProtKB/TrEMBL
      Q6IFR3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NGY5.1 GenPept UniProtKB/Swiss-Prot:Q8NGY5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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