Unc5b unc-5 netrin receptor B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Unc5bprovided by RGD
Official Full Name: unc-5 netrin receptor Bprovided by RGD
Primary source: RGD:621756
See related: EnsemblRapid:ENSRNOG00000000567 AllianceGenome:RGD:621756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Unc5h2
Summary: Enables netrin receptor activity. Involved in axon guidance and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in membrane raft. Orthologous to human UNC5B (unc-5 netrin receptor B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 80.7), Lung (RPKM 76.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (29240639..29307270, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (28697726..28764474, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (30339680..30406593, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UNC5B Overexpression Alleviates Peripheral Neuropathic Pain by Stimulating Netrin-1-Dependent Autophagic Flux in Schwann Cells.
Title: UNC5B Overexpression Alleviates Peripheral Neuropathic Pain by Stimulating Netrin-1-Dependent Autophagic Flux in Schwann Cells.
Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury.
Title: Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury.
the Unc5B receptor and subsequent activation of the tyrosine phosphatase SHP2 mediated Netrin-4-induced pain signaling in the spinal cord.
Title: Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B.
Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor.
Title: Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor.
Treadmill exercise has beneficial effects via involvement of netrin-1 and its receptors DCC and Unc5B in neuronal and vascular activities in brain-ischemic rats.
Title: Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia.
Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
Title: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
These data suggest that netrin-1 could be an endogenous trophic factor for Schwann cells in the injured peripheral nerves.
Title: Netrin-1 induces proliferation of Schwann cells through Unc5b receptor.

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General gene information

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Markers

Unc5h2 (e-PCR), detects polymorphism
- UniSTS:259457

D7S512 (e-PCR)
- UniSTS:70294

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables netrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables netrin receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axon guidance	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: netrin receptor UNC5B

Names: protein unc-5 homolog 2; protein unc-5 homolog B; transmembrane receptor Unc5H2; unc-5 homolog 2; unc-5 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022207.2 → NP_071543.2 netrin receptor UNC5B precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

O08722

UniProtKB/TrEMBL

A0A8I6AKI5

Related

ENSRNOP00000093505.1, ENSRNOT00000109345.2

Conserved Domains (6) summary

smart00218
Location:542 → 645

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08802
Location:859 → 942

Death_UNC5B; Death domain found in Uncoordinated-5B

smart00209
Location:250 → 301

TSP1; Thrombospondin type 1 repeats

pfam17217
Location:692 → 831

UPA; UPA domain

cd00096
Location:162 → 166

Ig; Ig strand A' [structural motif]

cl11960
Location:158 → 244

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

29240639..29307270 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256423.5 → XP_006256485.1 netrin receptor UNC5B isoform X3

UniProtKB/Swiss-Prot

O08722

UniProtKB/TrEMBL

A0A8I6A411

Related

ENSRNOP00000087913.1, ENSRNOT00000102258.2

Conserved Domains (6) summary

smart00218
Location:531 → 634

ZU5; Domain present in ZO-1 and Unc5-like netrin receptors

cd08802
Location:848 → 931

Death_UNC5B; Death domain found in Uncoordinated-5B

smart00209
Location:250 → 301

TSP1; Thrombospondin type 1 repeats

smart00410
Location:55 → 142

IG_like; Immunoglobulin like

pfam07679
Location:156 → 244

I-set; Immunoglobulin I-set domain

cl11960
Location:158 → 244

Ig; Immunoglobulin domain
XM_063279490.1 → XP_063135560.1 netrin receptor UNC5B isoform X2

UniProtKB/TrEMBL

F1LNE2
XM_063279489.1 → XP_063135559.1 netrin receptor UNC5B isoform X1

UniProtKB/TrEMBL

F1LNE2

Related

ENSRNOP00000112200.1, ENSRNOT00000162949.1