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    Acss3 acyl-CoA synthetase short-chain family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314800, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Acss3provided by RGD
    Official Full Name
    acyl-CoA synthetase short-chain family member 3provided by RGD
    Primary source
    RGD:1307051
    See related
    EnsemblRapid:ENSRNOG00000004448 AllianceGenome:RGD:1307051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307051
    Summary
    Enables acetate-CoA ligase activity; medium-chain fatty acid-CoA ligase activity; and propionate-CoA ligase activity. Predicted to be involved in lipid metabolic process. Located in mitochondrial matrix. Orthologous to human ACSS3 (acyl-CoA synthetase short chain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 449.1), Liver (RPKM 411.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acss3 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (44127725..44336707, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (42241261..42450209, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (49047022..49250953, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 25 Neighboring gene coiled-coil domain containing 59 Neighboring gene uncharacterized LOC134479682 Neighboring gene PTPRF interacting protein alpha 2 Neighboring gene sulfotransferase 1C2 pseudogene Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134479592

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix. Yoshimura Y, et al. J Biochem, 2017 Mar 1. PMID 28003429
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggested that ACSS3 is a liver mitochondrial matrix enzyme with high affinity to propionic acid, and its expression level is upregulated under ketogenic conditions.
      Title: Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables medium-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables propionate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables propionate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables propionate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA synthetase short-chain family member 3, mitochondrial
    Names
    acetate--CoA ligase 3
    propionate--CoA ligase
    NP_001101561.1
    NP_001401870.1
    XP_006241365.1
    XP_038935035.1
    XP_038935036.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108091.2 → NP_001101561.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001101561.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6IGC2, D3ZGU2
      Related
      ENSRNOP00000062459.1, ENSRNOT00000066975.3
      Conserved Domains (1) summary
      cl17068
      Location:68 → 479
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_001414941.1 → NP_001401870.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      A0A0G2K047
      Related
      ENSRNOP00000071300.1, ENSRNOT00000082141.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      44127725..44336707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079107.2 → XP_038935035.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cd05967
      Location:1 → 571
      PrpE; Propionyl-CoA synthetase (PrpE)

    2. XM_006241303.5 → XP_006241365.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006241365.1

      Conserved Domains (1) summary
      cd05967
      Location:1 → 571
      PrpE; Propionyl-CoA synthetase (PrpE)

    3. XM_039079108.2 → XP_038935036.1  acyl-CoA synthetase short-chain family member 3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl17068
      Location:58 → 447
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0G2K047.1 GenPept UniProtKB/Swiss-Prot:A0A0G2K047

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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