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    Dhrs11 dehydrogenase/reductase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360583, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dhrs11provided by RGD
    Official Full Name
    dehydrogenase/reductase 11provided by RGD
    Primary source
    RGD:1307935
    See related
    EnsemblRapid:ENSRNOG00000027891 AllianceGenome:RGD:1307935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307935
    Summary
    Predicted to enable 3-keto sterol reductase activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in steroid biosynthetic process. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 174.8), Heart (RPKM 164.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhrs11 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70195637..70205735, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69698214..69708294, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72144042..72153496, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480634 Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene gametogenetin binding protein 2 Neighboring gene zinc finger, HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Endo S, et al. Biochem Biophys Res Commun, 2016 Mar 25. PMID 26920053
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 17-beta-ketosteroid reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3-keto sterol reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dehydrogenase/reductase SDR family member 11
    Names
    dehydrogenase/reductase (SDR family) member 11
    NP_001014141.2
    XP_008766291.3
    XP_038942294.1
    XP_038942295.1
    XP_038942296.2
    XP_038942300.1
    XP_063125454.1
    XP_063125455.1
    XP_063125456.1
    XP_063125457.1
    XP_063125458.1
    XP_063125460.1
    XP_063125461.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014119.2 → NP_001014141.2  dehydrogenase/reductase SDR family member 11

      See identical proteins and their annotated locations for NP_001014141.2

      Status: VALIDATED

      Source sequence(s)
      BC088444, DY311021
      UniProtKB/TrEMBL
      A6HHL9
      Conserved Domains (2) summary
      cd05343
      Location:6 → 256
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs
      COG4221
      Location:6 → 259
      YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70195637..70205735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086368.2 → XP_038942296.2  dehydrogenase/reductase SDR family member 11 isoform X9

    2. XM_008768069.4 → XP_008766291.3  dehydrogenase/reductase SDR family member 11 isoform X3

    3. XM_063269385.1 → XP_063125455.1  dehydrogenase/reductase SDR family member 11 isoform X2

    4. XM_039086366.2 → XP_038942294.1  dehydrogenase/reductase SDR family member 11 isoform X4

      UniProtKB/TrEMBL
      G3V978
      Related
      ENSRNOP00000038582.4, ENSRNOT00000030841.6
      Conserved Domains (1) summary
      cd05343
      Location:76 → 295
      Mgc4172-like_SDR_c; human Mgc4172-like, classical (c) SDRs

    5. XM_063269384.1 → XP_063125454.1  dehydrogenase/reductase SDR family member 11 isoform X1

    6. XM_063269390.1 → XP_063125460.1  dehydrogenase/reductase SDR family member 11 isoform X10

    7. XM_039086372.2 → XP_038942300.1  dehydrogenase/reductase SDR family member 11 isoform X12

      Conserved Domains (2) summary
      PRK07985
      Location:31 → 109
      PRK07985; SDR family oxidoreductase
      cl21454
      Location:76 → 171
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    8. XM_063269387.1 → XP_063125457.1  dehydrogenase/reductase SDR family member 11 isoform X6

    9. XM_039086367.2 → XP_038942295.1  dehydrogenase/reductase SDR family member 11 isoform X7

      Conserved Domains (1) summary
      cl21454
      Location:6 → 186
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    10. XM_063269388.1 → XP_063125458.1  dehydrogenase/reductase SDR family member 11 isoform X8

    11. XM_063269386.1 → XP_063125456.1  dehydrogenase/reductase SDR family member 11 isoform X5

    12. XM_063269391.1 → XP_063125461.1  dehydrogenase/reductase SDR family member 11 isoform X11

    Nucleotide Protein Strain
    Heading Accession and Version

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