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    Carhsp1 calcium regulated heat stable protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 260416, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Carhsp1provided by RGD
    Official Full Name
    calcium regulated heat stable protein 1provided by RGD
    Primary source
    RGD:708415
    See related
    EnsemblRapid:ENSRNOG00000002610 AllianceGenome:RGD:708415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crhsp24; Crhsp-24
    Summary
    Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule and cytosol. Predicted to be part of cytoplasmic exosome (RNase complex). Predicted to be active in cytoplasm. Orthologous to human CARHSP1 (calcium regulated heat stable protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 134.0), Lung (RPKM 105.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Carhsp1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (7453602..7467218)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (6946036..6960556)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (7041510..7055107)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 7 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene Neighboring gene LITAF domain containing Neighboring gene phosphomannomutase 2 Neighboring gene transmembrane protein 186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A multistep validation process of biomarkers for preclinical drug development. Freeman WM, et al. Pharmacogenomics J, 2010 Oct. PMID 19997081
    2. Identification of calcineurin regulated phosphorylation sites on CRHSP-24. Lee S, et al. Biochem Biophys Res Commun, 2009 Jul 31. PMID 19477163, Free PMC Article
    3. Cyclosporin A inhibits Ca2+/calmodulin-dependent protein phosphatase and secretion in pancreatic acinar cells. Groblewski GE, et al. J Biol Chem, 1994 May 27. PMID 7515049
    4. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. Groblewski GE, et al. J Biol Chem, 1998 Aug 28. PMID 9712905
    5. CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells. Schäfer C, et al. Am J Physiol Gastrointest Liver Physiol, 2003 Oct. PMID 12801884

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coordinate phosphorylation of four serines explains the multiple phosphorylated isoforms of CRHSP-24 present in acinar cells.
      Title: Identification of calcineurin regulated phosphorylation sites on CRHSP-24.
    2. data indicate that calcium-regulated heat-stable protein-24 is regulated by diverse and physiologically relevant signaling pathways in pancreatic acinar cells
      Title: CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells.
    3. The purification and identification of CRHSP24 in rat liver extracts, and its role as a substrate for multiple enzymes are reported.
      Title: Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in P granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    calcium-regulated heat stable protein 1
    Names
    calcium-regulated heat-stable protein (24kD)
    calcium-regulated heat-stable protein of 24 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152790.3 → NP_690003.1  calcium-regulated heat stable protein 1

      See identical proteins and their annotated locations for NP_690003.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q9WU49
      UniProtKB/TrEMBL
      A0A8I6AMM1, A6K4L7
      Related
      ENSRNOP00000102913.1, ENSRNOT00000158886.1
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      7453602..7467218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245753.5 → XP_006245815.1  calcium-regulated heat stable protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMT7, A0A8I6AMM1
      Related
      ENSRNOP00000003514.4, ENSRNOT00000003514.7
      Conserved Domains (1) summary
      cd04458
      Location:83 → 148
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    2. XM_039085307.2 → XP_038941235.2  calcium-regulated heat stable protein 1 isoform X3

    3. XM_006245750.5 → XP_006245812.2  calcium-regulated heat stable protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9WU49
      UniProtKB/TrEMBL
      A0A8I6AMM1, A6K4L7
      Conserved Domains (1) summary
      cd04458
      Location:63 → 128
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

    4. XM_039085306.2 → XP_038941234.2  calcium-regulated heat stable protein 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WU49.1 GenPept UniProtKB/Swiss-Prot:Q9WU49

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