Myf6 myogenic factor 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myf6provided by RGD
Official Full Name: myogenic factor 6provided by RGD
Primary source: RGD:3134
See related: EnsemblRapid:ENSRNOG00000004878 AllianceGenome:RGD:3134
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MRF4AA
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in skeletal muscle tissue regeneration. Predicted to be located in cytosol; mitotic spindle; and nucleoplasm. Human ortholog(s) of this gene implicated in congenital structural myopathy. Orthologous to human MYF6 (myogenic factor 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 474.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (44699469..44701313, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (42813008..42814852, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (49739643..49741490, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRF4 acts by stabilizing a repressor complex that controls MEF2 activity.
Title: MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity.
Decreased myostatin expression combined with significant muscle atrophy is observed in spontaneously hypertensive rats (SHR) with heart failure; MRF4 levels positively correlate with type I MyHC isoform.
Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
the timing of up-regulation can determine the progress of muscle regeneration
Title: Regeneration of transgenic skeletal muscles with altered timing of expression of the basic helix-loop-helix muscle regulatory factor MRF4.
MRF4 is co-expressed with MyoD and myogenin in nuclei of regenerating myotubes and young myofibers, but it is not expressed in satellite cells.
Title: MRF4 protein expression in regenerating rat muscle.

Submit: New GeneRIF Correction

General gene information

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Markers

Myf6 (e-PCR), detects polymorphism
- UniSTS:143947

Myf6 (e-PCR), detects polymorphism
- UniSTS:143948

Myf6 (e-PCR), detects polymorphism
- UniSTS:265669

MARC_21230-21231:1032890530:1 (e-PCR)
- UniSTS:268513

RH94559 (e-PCR)
- UniSTS:119807

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of skeletal muscle fiber development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myogenic factor 6

Names: Myogenic factor 6 (herculin); muscle-specific regulatory factor 4; myf-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013172.2 → NP_037304.1 myogenic factor 6

See identical proteins and their annotated locations for NP_037304.1

Status: PROVISIONAL

Source sequence(s)

M27151

UniProtKB/Swiss-Prot

P19335

UniProtKB/TrEMBL

A6IGD0

Related

ENSRNOP00000006523.4, ENSRNOT00000006523.7

Conserved Domains (2) summary

cd18934
Location:93 → 156

bHLH_TS_MRF4_Myf6; basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and similar proteins

cl11603
Location:3 → 98

Basic; Myogenic Basic domain