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    Tmem17 transmembrane protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360985, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem17provided by RGD
    Official Full Name
    transmembrane protein 17provided by RGD
    Primary source
    RGD:1310566
    See related
    EnsemblRapid:ENSRNOG00000009220 AllianceGenome:RGD:1310566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in non-motile cilium assembly and smoothened signaling pathway. Predicted to be located in ciliary membrane. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. Orthologous to human TMEM17 (transmembrane protein 17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 55.3), Adrenal (RPKM 53.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem17 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (100684655..100725471)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (96483648..96524238)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (107268235..107308546)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene EH domain binding protein 1 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene uncharacterized LOC134481801 Neighboring gene uncharacterized LOC134481802 Neighboring gene transfer RNA proline (anticodon AGG) 86 Neighboring gene vasculin-like protein 1-like Neighboring gene ribosomal protein L28 like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. Li C, et al. PLoS Biol, 2016 Mar. PMID 26982032, Free PMC Article
    2. A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Chih B, et al. Nat Cell Biol, 2011 Dec 18. PMID 22179047
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in non-motile cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of MKS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MKS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary transition zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010961.2 → NP_001010961.1  transmembrane protein 17

      See identical proteins and their annotated locations for NP_001010961.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/Swiss-Prot
      Q5HZE5
      UniProtKB/TrEMBL
      A6JQ51
      Conserved Domains (1) summary
      pfam09799
      Location:48 → 151
      Transmemb_17; Predicted membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      100684655..100725471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092230.2 → XP_038948158.1  transmembrane protein 17 isoform X2

      Conserved Domains (1) summary
      pfam09799
      Location:48 → 106
      Transmemb_17; Predicted membrane protein

    2. XM_017599320.3 → XP_017454809.1  transmembrane protein 17 isoform X1

      UniProtKB/Swiss-Prot
      Q5HZE5
      UniProtKB/TrEMBL
      A6JQ51
      Conserved Domains (1) summary
      pfam09799
      Location:48 → 151
      Transmemb_17; Predicted membrane protein

    3. XM_017599321.3 → XP_017454810.1  transmembrane protein 17 isoform X1

      UniProtKB/Swiss-Prot
      Q5HZE5
      UniProtKB/TrEMBL
      A6JQ51
      Related
      ENSRNOP00000012224.3, ENSRNOT00000012224.7
      Conserved Domains (1) summary
      pfam09799
      Location:48 → 151
      Transmemb_17; Predicted membrane protein

    4. XM_063273406.1 → XP_063129476.1  transmembrane protein 17 isoform X1

      UniProtKB/Swiss-Prot
      Q5HZE5
      UniProtKB/TrEMBL
      A6JQ51
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZE5.1 GenPept UniProtKB/Swiss-Prot:Q5HZE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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