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    Gar1 GAR1 ribonucleoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499709, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gar1provided by RGD
    Official Full Name
    GAR1 ribonucleoproteinprovided by RGD
    Primary source
    RGD:1563995
    See related
    AllianceGenome:RGD:1563995
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nola1
    Summary
    Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Involved in snoRNA guided rRNA pseudouridine synthesis. Part of box H/ACA snoRNP complex. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 13.6), Thymus (RPKM 13.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gar1 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (221049471..221056749, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (218375231..218382509, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (235250453..235258464, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat, Ig-like and transmembrane domains 3 Neighboring gene retinal pigment epithelium derived rhodopsin homolog Neighboring gene uncharacterized LOC134485966 Neighboring gene complement factor I Neighboring gene uncharacterized LOC120100942

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140. Wang C, et al. Mol Cell Biol, 2002 Dec. PMID 12446766, Free PMC Article
    2. The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA. Watkins NJ, et al. Wiley Interdiscip Rev RNA, 2012 May-Jun. PMID 22065625
    3. In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs. Dragon F, et al. Mol Cell Biol, 2000 May. PMID 10757788, Free PMC Article
    4. Cryo-EM structure of substrate-bound human telomerase holoenzyme. Nguyen THD, et al. Nature, 2018 May. PMID 29695869, Free PMC Article
    5. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Egan ED, et al. Mol Cell Biol, 2010 Jun. PMID 20351177, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables box H/ACA snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables box H/ACA snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables box H/ACA snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomerase RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via telomerase ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box H/ACA snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box H/ACA snoRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of box H/ACA snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box H/ACA snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of box H/ACA telomerase RNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box H/ACA telomerase RNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    H/ACA ribonucleoprotein complex subunit 1
    Names
    GAR1 homolog, ribonucleoprotein
    GAR1 ribonucleoprotein homolog
    nucleolar protein family A member 1
    nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)
    snoRNP protein GAR1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024306.1 → NP_001019477.1  H/ACA ribonucleoprotein complex subunit 1

      See identical proteins and their annotated locations for NP_001019477.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079131
      UniProtKB/Swiss-Prot
      Q6AYA1
      UniProtKB/TrEMBL
      A6HVP9, A6HVQ1
      Conserved Domains (1) summary
      pfam04410
      Location:63 → 169
      Gar1; Gar1/Naf1 RNA binding region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      221049471..221056749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYA1.1 GenPept UniProtKB/Swiss-Prot:Q6AYA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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