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    Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcnj15provided by RGD
    Official Full Name
    potassium inwardly-rectifying channel, subfamily J, member 15provided by RGD
    Primary source
    RGD:621662
    See related
    EnsemblRapid:ENSRNOG00000062944 AllianceGenome:RGD:621662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kir4.2
    Summary
    Enables inward rectifier potassium channel activity. Predicted to be involved in potassium ion import across plasma membrane and regulation of monoatomic ion transmembrane transport. Predicted to act upstream of or within potassium ion transmembrane transport. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNJ15 (potassium inwardly rectifying channel subfamily J member 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 447.5) and Lung (RPKM 52.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnj15 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (48046953..48091285)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (34577397..34621725)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (35545185..35588517)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352313 Neighboring gene uncharacterized LOC120095565 Neighboring gene uncharacterized LOC102550135 Neighboring gene ETS transcription factor ERG Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120095640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression. Earley S, et al. Am J Physiol Lung Cell Mol Physiol, 2002 Jul. PMID 12060564
    2. Cloning, expression, and localization of a rat hepatocyte inwardly rectifying potassium channel. Hill CE, et al. Am J Physiol Gastrointest Liver Physiol, 2002 Feb. PMID 11804844
    3. Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver. Pearson WL, et al. J Physiol, 1999 Feb 1. PMID 9882736, Free PMC Article
    4. Inhibition of glucose-stimulated insulin secretion by KCNJ15, a newly identified susceptibility gene for type 2 diabetes. Okamoto K, et al. Diabetes, 2012 Jul. PMID 22566534, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-sensitive inward rectifier potassium channel 15
    Names
    inward rectifier K(+) channel Kir4.2
    potassium channel, inwardly rectifying subfamily J member 15
    potassium voltage-gated channel subfamily J member 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433865.1 → NP_001420794.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9

    2. NM_001433866.1 → NP_001420795.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9

    3. NM_001433867.1 → NP_001420796.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9

    4. NM_001433868.1 → NP_001420797.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9

    5. NM_001433869.1 → NP_001420798.1  ATP-sensitive inward rectifier potassium channel 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8L2PZJ4

    6. NM_001433870.1 → NP_001420799.1  ATP-sensitive inward rectifier potassium channel 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8L2PZJ4

    7. NM_001433871.1 → NP_001420800.1  ATP-sensitive inward rectifier potassium channel 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8L2PZJ4

    8. NM_133321.3 → NP_579855.1  ATP-sensitive inward rectifier potassium channel 15 isoform 1

      See identical proteins and their annotated locations for NP_579855.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9
      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      48046953..48091285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248128.5 → XP_006248190.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      See identical proteins and their annotated locations for XP_006248190.1

      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9
      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    2. XM_006248131.5 → XP_006248193.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    3. XM_039087927.2 → XP_038943855.1  ATP-sensitive inward rectifier potassium channel 15 isoform X3

      UniProtKB/TrEMBL
      A0A8L2PZJ4
      Conserved Domains (2) summary
      pfam01007
      Location:49 → 190
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:197 → 368
      IRK_C; Inward rectifier potassium channel C-terminal domain

    4. XM_063270252.1 → XP_063126322.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9

    5. XM_008768550.4 → XP_008766772.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      See identical proteins and their annotated locations for XP_008766772.1

      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9
      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    6. XM_006248129.5 → XP_006248191.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    7. XM_006248132.5 → XP_006248194.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      See identical proteins and their annotated locations for XP_006248194.1

      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9
      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    8. XM_008768552.4 → XP_008766774.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      See identical proteins and their annotated locations for XP_008766774.1

      UniProtKB/Swiss-Prot
      Q91ZF1
      UniProtKB/TrEMBL
      A0A8L2PZJ4, A6KPU9
      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    9. XM_006248133.5 → XP_006248195.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    10. XM_039087926.2 → XP_038943854.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

      Related
      ENSRNOP00000078466.1, ENSRNOT00000108557.2
      Conserved Domains (2) summary
      pfam01007
      Location:30 → 171
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:178 → 349
      IRK_C; Inward rectifier potassium channel C-terminal domain

    11. XM_006248139.5 → XP_006248201.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

      Related
      ENSRNOP00000089124.1, ENSRNOT00000104151.2
      Conserved Domains (2) summary
      pfam01007
      Location:30 → 171
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:178 → 349
      IRK_C; Inward rectifier potassium channel C-terminal domain

    12. XM_039087925.2 → XP_038943853.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

      Related
      ENSRNOP00000093558.1, ENSRNOT00000111664.2
      Conserved Domains (2) summary
      pfam01007
      Location:30 → 171
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:178 → 349
      IRK_C; Inward rectifier potassium channel C-terminal domain

    13. XM_006248135.4 → XP_006248197.1  ATP-sensitive inward rectifier potassium channel 15 isoform X1

      Conserved Domains (1) summary
      pfam01007
      Location:60 → 386
      IRK; Inward rectifier potassium channel

    14. XM_039087924.2 → XP_038943852.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

      UniProtKB/TrEMBL
      A0A8L2PZJ4
      Related
      ENSRNOP00000098859.1, ENSRNOT00000165093.1
      Conserved Domains (2) summary
      pfam01007
      Location:30 → 171
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:178 → 349
      IRK_C; Inward rectifier potassium channel C-terminal domain

    15. XM_006248141.5 → XP_006248203.1  ATP-sensitive inward rectifier potassium channel 15 isoform X2

      See identical proteins and their annotated locations for XP_006248203.1

      UniProtKB/TrEMBL
      A0A8L2PZJ4
      Related
      ENSRNOP00000091174.1, ENSRNOT00000099760.2
      Conserved Domains (2) summary
      pfam01007
      Location:30 → 171
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:178 → 349
      IRK_C; Inward rectifier potassium channel C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZF1.1 GenPept UniProtKB/Swiss-Prot:Q91ZF1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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