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    Prmt9 protein arginine methyltransferase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prmt9provided by RGD
    Official Full Name
    protein arginine methyltransferase 9provided by RGD
    Primary source
    RGD:1306157
    See related
    EnsemblRapid:ENSRNOG00000012928 AllianceGenome:RGD:1306157
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prmt10; RGD1306157
    Summary
    Predicted to enable histone methyltransferase activity and protein-arginine omega-N symmetric methyltransferase activity. Predicted to be involved in chromatin remodeling; mRNA processing; and regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Orthologous to human PRMT9 (protein arginine methyltransferase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 121.1), Thymus (RPKM 119.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prmt9 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (47257974..47318719, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (30376342..30414491, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (34067008..34105626, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098594 Neighboring gene endothelin receptor type A Neighboring gene uncharacterized LOC134483343 Neighboring gene transmembrane protein 184C Neighboring gene Rho GTPase activating protein 10 Neighboring gene uncharacterized LOC134483344 Neighboring gene membrane-associated progesterone receptor component 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. Hadjikyriacou A, et al. J Biol Chem, 2015 Jul 3. PMID 25979344, Free PMC Article
    2. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Yang Y, et al. Nat Commun, 2015 Mar 4. PMID 25737013, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine omega-N symmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein arginine N-methyltransferase 9
    Names
    protein arginine methyltransferase 10 (putative)
    putative protein arginine N-methyltransferase 10
    putative protein arginine N-methyltransferase 9
    NP_001178528.1
    XP_006255486.1
    XP_063133967.1
    XP_063133968.1
    XP_063133969.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191599.1 → NP_001178528.1  protein arginine N-methyltransferase 9

      See identical proteins and their annotated locations for NP_001178528.1

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AMT6, D3ZDR5
      Related
      ENSRNOP00000017347.6, ENSRNOT00000017347.9
      Conserved Domains (3) summary
      sd00006
      Location:68 → 95
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:68 → 132
      TPR_11; TPR repeat
      cl17173
      Location:148 → 338
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      47257974..47318719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255424.5 → XP_006255486.1  protein arginine N-methyltransferase 9 isoform X1

      See identical proteins and their annotated locations for XP_006255486.1

      UniProtKB/TrEMBL
      A0A8I6AMT6, D3ZDR5
      Conserved Domains (3) summary
      sd00006
      Location:68 → 95
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:68 → 132
      TPR_11; TPR repeat
      cl17173
      Location:148 → 338
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_063277897.1 → XP_063133967.1  protein arginine N-methyltransferase 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AMT6

    3. XM_063277898.1 → XP_063133968.1  protein arginine N-methyltransferase 9 isoform X3

      UniProtKB/TrEMBL
      A6IYK7

    4. XM_063277899.1 → XP_063133969.1  protein arginine N-methyltransferase 9 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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